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Table 4 Dose-response relationship between inhaled nitric oxide and the risk of acute kidney injury

From: Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials

Cumulative dose of inhaled nitric oxide

Numer of studies (number of patients)

Risk ratio of AKI (95% CI)

P -value (test for effect)

Heterogeneity

References

Low

2 (109)

0.56 (0.11 to 2.86)

0.49

I 2 = 0%

[22,25]

Medium

3 (159)

0.64 (0.23 to 1.81)

0.40

I 2 = 0%

[24,27,28]

High

5 (1069)

1.52 (1.14 to 2.02)

0.004

I 2 = 0%

[12,20,21,23,26]

  1. AKI, acute kidney injury.
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Critical Care

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