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Table 4 Dose-response relationship between inhaled nitric oxide and the risk of acute kidney injury

From: Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials

Cumulative dose of inhaled nitric oxide Numer of studies (number of patients) Risk ratio of AKI (95% CI) P -value (test for effect) Heterogeneity References
Low 2 (109) 0.56 (0.11 to 2.86) 0.49 I 2 = 0% [22,25]
Medium 3 (159) 0.64 (0.23 to 1.81) 0.40 I 2 = 0% [24,27,28]
High 5 (1069) 1.52 (1.14 to 2.02) 0.004 I 2 = 0% [12,20,21,23,26]
  1. AKI, acute kidney injury.