Dellinger (1998) [12]
|
USA
|
ARDS
|
1.25, 5.0, 20.0, 40.0, or 80.0 ppm iNO for 28 days or till FiO2 < 0.5
|
21 ppm
|
48
|
Creatinine >2 mg/dL
|
20/120
|
7/57
|
Creatinine ≥3.5 mg/dL
|
13/120
|
5/57
|
Lundin (1999) [20]
|
11 European countries
|
ARDS
|
1 to 40 ppm iNO at the lowest effective dose for up to 30 days or until an end point was reached
|
9 ppm
|
57
|
Creatinine >3.4 mg/dL or RRT
|
28/80
|
12/74
|
Incident RRT
|
23/84
|
10/79
|
Kinsella (1999) [22]
|
USA
|
Neonate hypoxemic respiratory failure
|
5 ppm for 7 days
|
5 ppm
|
27 weeks
|
Renal failure
|
2/48
|
2/32
|
Payen (1999) [21]
|
Europe
|
ARDS
|
10 ppm till PF >250, median 5 days
|
10 ppm
|
Not reported
|
RRT
|
33/98
|
26/105
|
Taylor (2004) [23]
|
USA
|
ARDS
|
5 ppm until 28 days, discontinuation of assisted breathing, or death
|
5 ppm
|
50
|
Creatinine ≥3 mg/dL
|
12/192
|
8/193
|
Creatinine ≥3.5 mg/dL
|
10/192
|
6/193
|
Perrin (2006) [24]
|
France
|
Lung transplantation
|
20 ppm for 12 h
|
20 ppm
|
35
|
RRT
|
1/15
|
1/15
|
Potapov (2011) [26]
|
USA and Germany
|
Cardiac surgery
|
40 ppm for 48 h
|
40 ppm
|
56
|
RRT
|
10/73
|
8/77
|
Fernandes (2011) [25]
|
Brazil
|
Cardiac surgery
|
10 ppm for 48 h
|
10 ppm
|
46
|
Urine output <0.3 ml/kg/h
|
0/14
|
1/15
|
Lang (2014) [28]
|
USA
|
Liver transplantation
|
80 ppm during the operative phase
|
80 ppm
|
56
|
Renal dysfunction
|
3/40
|
7/40
|
Trzeciak (2014) [27]
|
USA
|
Sepsis
|
40 ppm for 6 h
|
40 ppm
|
59
|
RRT
|
2/26
|
1/23
|