Table 1 Clinical conditions between different types of fluid status before continuous renal replacement therapy
Fluid status | Total | Type 1 | Type 2 | Type 3 | Type 4 | P value |
|---|---|---|---|---|---|---|
Number (%) | 89 (100) | 19 (21.3) | 15 (16.9) | 10 (11.2) | 45 (50.6) | |
Male/female | 58/31 | 13/6 | 9/6 | 9/1 | 27/18 | 0.319 |
Age, years | 49.0 ± 17.2 | 45.5 ± 15.1 | 44.7 ± 16.6 | 43.3 ± 17.9 | 53.1 ± 17.7 | 0.148 |
Height, cm | 167.9 ± 10.4 | 168.5 ± 7.0 | 166.2 ± 8.8 | 176.9 ± 6.2 | 166.4 ± 12.0 | 0.015 |
Weight, kg | 70.4 ± 15.8 | 69.0 ± 23.1 | 63.2 ± 10.0 | 78.5 ± 14.5 | 72.0 ± 12.7 | 0.023 |
Primary reason for hospitalization, n (%) | ||||||
Pancreatic | 28 (31.4) | 11 (57.9) | 2 (13.3) | 4 (40.0) | 11 (24.4) | 0.021 |
Gastrointestinal | 27 (30.3) | 5 (26.3) | 3 (20.0) | 4 (40.0) | 15 (33.3) | 0.678 |
Liver | 4 (4.5) | 2 (10.5) | 1 (6.7) | 0 | 1 (2.2) | 0.431 |
Pulmonary | 9 (10.1) | 0 | 3 (20.0) | 1 (10.0) | 5 (11.1) | 0.289 |
Trauma | 8 (9.0) | 0 | 1 (6.7) | 1 (10.0) | 6 (13.3) | 0.393 |
Other | 13 (9.0) | 1 (5.3) | 5 (33.3) | 0 | 7 (15.5) | 0.066 |
Acute kidney injury, n (%) | 60 (67.4) | 7 (36.8) | 9 (60.0) | 6 (60.0) | 38 (84.4) | 0.002 |
Acute heart failure, n (%) | 24 (27.0) | 0 | 4 (26.7) | 1 (10.0) | 19 (42.2) | 0.003 |
Severe sepsis, n (%) | 63 (70.8) | 10 (52.6) | 8 (53.3) | 9 (90.0) | 36 (80.0) | 0.032 |
Mechanical ventilation, n (%) | 54 (60.7) | 6 (31.6) | 7 (46.7) | 6 (60.0) | 36 (80.0) | 0.002 |
Comorbidities, n (%) | ||||||
Diabetes mellitus | 11 (12.3) | 2 (10.5) | 3 (20.0) | 0 | 6 (13.3) | 0.514 |
Chronic heart failure | 4 (4.5) | 0 | 2 (13.3) | 0 | 2 (4.4) | 0.256 |
Chronic renal failure | 7 (7.9) | 0 | 6 (40.0) | 0 | 1 (2.2) | <0.001 |
Urea, mmol/L | 17.9 ± 12.7 | 13.6 ± 13.9 | 18.3 ± 12.6 | 16.3 ± 14.3 | 20.1 ± 11.8 | 0.301 |
Creatinine, μmol/L | 287.5 ± 290.0 | 119.6 ± 138.3 | 496.7 ± 457.3 | 176.5 ± 191.0 | 313.2 ± 236.1 | 0.001 |
Oliguria, n (%) | 45 (50.6%) | 3 (15.8%) | 11 (73.3%) | 5 (50%) | 26 (57.8%) | 0.004 |
Urine output, mL/day | 803 ± 796 | 1,309 ± 652 | 429 ± 388 | 916 ± 755 | 732 ± 878 | 0.008 |
Hemoglobin, g/L | 103.5 ± 32.4 | 121.1 ± 34.2 | 109.9 ± 40.7 | 96.8 ± 16.0 | 95.5 ± 28.6 | 0.022 |
Platelet, ×109/L | 136.0 ± 88.7 | 186.5 ± 70.2 | 165.7 ± 114.7 | 106.7 ± 75.7 | 111.2 ± 78.3 | 0.005 |
CRP, mg/L | 133.4 ± 78.0 | 114.3 ± 70.4 | 105.4 ± 77.3 | 165.8 ± 73.2 | 141.7 ± 80.0 | 0.177 |
Albumin, g/L | 30.3 ± 4.9 | 29.2 ± 5.1 | 32 ± 6.8 | 29.7 ± 3.5 | 30.3 ± 4.4 | 0.419 |
Bilirubin, mmol/La | 27.6 (14.4-37.8) | 23.3 (17.3-51.4) | 10.0 (6.4-64.8) | 45.5 (16.9-100.3) | 27.6 (16.3-85.4) | 0.304 |
Lactate, mmol/La | 2.1 (1.3-3.8) | 2.1 (1.5-3.4) | 1.9 (1.3-3.8) | 1.8 (1.3-3.5) | 2.4 (1.3-3.9) | 0.952 |
NT-ProBNP, pmol/La | 274 (62-1,491) | 15.4 (8.5-54) | 591 (203-1,949) | 61 (51-65) | 817 (294-2,549) | <0.001 |
APACHE II score | 18.8 ± 8.6 | 13.6 ± 6.7 | 17.1 ± 7.5 | 15.5 ± 8.4 | 22.2 ± 8.3 | <0.001 |
SOFA score | 11.7 ± 6.0 | 6.6 ± 3.0 | 10.6 ± 5.1 | 10.7 ± 6.4 | 14.6 ± 5.6 | <0.001 |
SAPS II | 41.7 ± 18.5 | 19.7 ± 12.7 | 42.5 ± 18.3 | 34.8 ± 22.2 | 48.4 ± 17.0 | <0.001 |
Fluid balance at day 1, mLa | 1,134 (169-2,301) | 966 (210-1,702) | 1,734 (602-3,092) | 1,514 (670-2,157) | 1,118 (−334-2,499) | 0.557 |
Cumulative fluid balance over 3 days, mLa | 2,729 (676-4,883) | 2,729 (676-4,883) | 3,843 (2,515-4,824) | 2,517 (514-5,571) | 2,611(−993-5,282) | 0.7935 |