Paracetamol therapy and outcome of critically ill patients: a multicenter retrospective observational study

Table 4 Adjusted hazards ratio for in-hospital mortality with paracetamol administration as a time-dependent variable^a

	N	Adjusted HR (95% CI)	P -value
All^b	15,818	0.68 (0.61 to 0.75)	<0.001
Surgery^c
Yes	9,994	0.64 (0.53 to 0.77)	<0.001
No	5,824	0.72 (0.64 to 0.81)	<0.001
Fever^d
Yes	4,397	0.84 (0.72 to 0.98)	0.02
No	11,421	0.58 (0.50 to 0.66)	<0.001
Medical, fever and infection^e	681	0.70 (0.49 to 0.99)	0.04

^aCI, Confidence interval; HR, Hazard ratio. ^bAdjusted for Acute Physiology and Chronic Health Evaluation (APACHE) II score, hospital, surgical patient, infection as admission diagnosis, presence of fever, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol). ^cAdjusted for APACHE II score, hospital, infection as admission diagnosis, presence of fever, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol). ^dAdjusted for APACHE II score, hospital, surgical patient, infection as admission diagnosis, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol). ^eAdjusted for APACHE II score, hospital, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol).

ISSN: 1364-8535