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Table 4 Adjusted hazards ratio for in-hospital mortality with paracetamol administration as a time-dependent variablea

From: Paracetamol therapy and outcome of critically ill patients: a multicenter retrospective observational study

  N Adjusted HR (95% CI) P -value
Allb 15,818 0.68 (0.61 to 0.75) <0.001
Surgeryc    
 Yes 9,994 0.64 (0.53 to 0.77) <0.001
 No 5,824 0.72 (0.64 to 0.81) <0.001
Feverd    
 Yes 4,397 0.84 (0.72 to 0.98) 0.02
 No 11,421 0.58 (0.50 to 0.66) <0.001
Medical, fever and infectione 681 0.70 (0.49 to 0.99) 0.04
  1. aCI, Confidence interval; HR, Hazard ratio. bAdjusted for Acute Physiology and Chronic Health Evaluation (APACHE) II score, hospital, surgical patient, infection as admission diagnosis, presence of fever, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol). cAdjusted for APACHE II score, hospital, infection as admission diagnosis, presence of fever, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol). dAdjusted for APACHE II score, hospital, surgical patient, infection as admission diagnosis, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol). eAdjusted for APACHE II score, hospital, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol).