Paracetamol therapy and outcome of critically ill patients: a multicenter retrospective observational study

Table 3 Adjusted odds ratios and hazards ratios for in-hospital mortality with the binary factor of paracetamol administration^a

	N	Adjusted OR (95% CI)	P -value	Adjusted HR (95% CI)	P -value
All^b	15,818	0.60 (0.53 to 0.68)	<0.001	0.51 (0.46 to 0.56)	<0.0001
Surgery^c
Yes	9,994	0.72 (0.58 to 0.91)	0.006	0.51 (0.42 to 0.61)	<0.0001
No	5,824	0.56 (0.48 to 0.66)	<0.001	0.51 (0.45 to 0.57)	<0.0001
Fever^d
Yes	4,397	0.76 (0.61 to 0.93)	0.009	0.57 (0.49 to 0.66)	<0.0001
No	11,421	0.54 (0.46 to 0.64)	<0.001	0.49 (0.43 to 0.56)	<0.0001
Medical, fever and infection^e	681	0.67 (0.42 to 1.05)	0.08	0.47 (0.33 to 0.65)	<0.0001

^aCI, Confidence interval; HR, Hazard ratio; OR, Odds ratio. ^bAdjusted for Acute Physiology and Chronic Health Evaluation (APACHE) II score, hospital, surgical patient, infection as admission diagnosis, presence of fever, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol). ^cAdjusted for APACHE II score, hospital, infection as admission diagnosis, presence of fever, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol). ^dAdjusted for APACHE II score, hospital, surgical patient, infection as admission diagnosis, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol). ^eAdjusted for APACHE II score, hospital, APACHE III admission diagnosis group, treatment limitation and propensity score (for receiving paracetamol).

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