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Table 1 Comparison of the characteristics of patients who received or did not receive at least one dose of paracetamola

From: Paracetamol therapy and outcome of critically ill patients: a multicenter retrospective observational study

  All patients, N =15,818 No paracetamol, n =5,772 Paracetamol, n =10,046 P -value
Age, yr 64 (51 to 73) 62 (49 to 73) 64 (52 to 73) <0.001
Male sex 64% (1,019) 63% (3,631) 65% (6,568) 0.002
 APACHE II score 16.9 (7.18) 17.7 (8.4) 16.5 (6.3) <0.001
 SAPS II score 29.5 (22.4) 28.3 (26.2) 30.2 (19.8) <0.001
Hospital A 20.3% (3,206) 14% (786) 24% (2,419) <0.001
Hospital B 10.9% (1,718) 11% (631) 11% (1,087) 0.83
Hospital C 10.2% (1,607) 12% (707) 9% (900) <0.001
Hospital D 58.7% (9,288) 63% (3,648) 56% (5,640) <0.001
Mechanical ventilationb 73% (11,513) 70% (4,032) 74% (7,481) <0.001
Acute renal failurec 6% (944) 8% (477) 5% (457) <0.001
Surgical admissionsd 63% (9,994) 51% (2,949) 70% (7,045) <0.001
Elective surgery 49% (7,707) 37% (2,154) 55% (5,553) <0.001
Infection as admission diagnosise 9% (1,419) 9% (518) 9% (901) 0.99
 Number of temperature measurements 15 (9 to 36) 11 (5 to 20) 18 (11 to 49) <0.001
 Mean temperature, °C 36.7 (0.7) 36.6 (0.8) 36.8 (0.6) <0.001
 Highest temperature, °C 37.6 (1.0) 37.4 (0.9) 37.8 (1.0) <0.001
 Lowest temperature, °C 35.4 (2.2) 35.6 (1.9) 35.4 (2.4) <0.001
 SD of temperature, °C 0.62 (0.46) 0.59 (0.50) 0.64 (0.43) <0.001
Temperature >38°Cf 28% (4,397) 18% (984) 34% (3,413) <0.001
Temperature >38.3°Cf 20.3% (3,212) 11% (647) 26% (2,565) <0.001
Temperature >38.5°Cf 15.5% (2,456) 7% (429) 20% (2,027) <0.001
Temperature >39°Cf 7.9% (1,247) 3% (174) 11% (1,073) <0.001
Temperature <35°Cf 37.6% (5,949) 33% (1,927) 40% (4,022) <0.001
 Total dose, g 1 (0 to 4) 0 (0 to 0) 3 (2 to 7) <0.001
 Mean daily dose,g g 1 (0 to 2) 0 (0 to 0) 1.9 (1.0 to 2.6) <0.001
  1. aAPACHE, Acute Physiology and Chronic Health Evaluation; SAPS, Simplified Acute Physiology Score; SD, Standard deviation. bMechanical ventilation within first 24 hours of ICU admission. c24-hour urine output is <410 ml AND creatinine >133 μmol/L AND patient is not receiving chronic dialysis. dAPACHE III-J principal postoperative diagnosis. eA list of admission diagnosis with infection is provided in Additional file 1. fIndicates the presence of a given temperature at any time during intensive care unit stay. gMean daily dose calculated by dividing total dose by number by treatment days.