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Table 1 Comparison of the characteristics of patients who received or did not receive at least one dose of paracetamola

From: Paracetamol therapy and outcome of critically ill patients: a multicenter retrospective observational study

 

All patients, N =15,818

No paracetamol, n =5,772

Paracetamol, n =10,046

P -value

Age, yr

64 (51 to 73)

62 (49 to 73)

64 (52 to 73)

<0.001

Male sex

64% (1,019)

63% (3,631)

65% (6,568)

0.002

 APACHE II score

16.9 (7.18)

17.7 (8.4)

16.5 (6.3)

<0.001

 SAPS II score

29.5 (22.4)

28.3 (26.2)

30.2 (19.8)

<0.001

Hospital A

20.3% (3,206)

14% (786)

24% (2,419)

<0.001

Hospital B

10.9% (1,718)

11% (631)

11% (1,087)

0.83

Hospital C

10.2% (1,607)

12% (707)

9% (900)

<0.001

Hospital D

58.7% (9,288)

63% (3,648)

56% (5,640)

<0.001

Mechanical ventilationb

73% (11,513)

70% (4,032)

74% (7,481)

<0.001

Acute renal failurec

6% (944)

8% (477)

5% (457)

<0.001

Surgical admissionsd

63% (9,994)

51% (2,949)

70% (7,045)

<0.001

Elective surgery

49% (7,707)

37% (2,154)

55% (5,553)

<0.001

Infection as admission diagnosise

9% (1,419)

9% (518)

9% (901)

0.99

 Number of temperature measurements

15 (9 to 36)

11 (5 to 20)

18 (11 to 49)

<0.001

 Mean temperature, °C

36.7 (0.7)

36.6 (0.8)

36.8 (0.6)

<0.001

 Highest temperature, °C

37.6 (1.0)

37.4 (0.9)

37.8 (1.0)

<0.001

 Lowest temperature, °C

35.4 (2.2)

35.6 (1.9)

35.4 (2.4)

<0.001

 SD of temperature, °C

0.62 (0.46)

0.59 (0.50)

0.64 (0.43)

<0.001

Temperature >38°Cf

28% (4,397)

18% (984)

34% (3,413)

<0.001

Temperature >38.3°Cf

20.3% (3,212)

11% (647)

26% (2,565)

<0.001

Temperature >38.5°Cf

15.5% (2,456)

7% (429)

20% (2,027)

<0.001

Temperature >39°Cf

7.9% (1,247)

3% (174)

11% (1,073)

<0.001

Temperature <35°Cf

37.6% (5,949)

33% (1,927)

40% (4,022)

<0.001

 Total dose, g

1 (0 to 4)

0 (0 to 0)

3 (2 to 7)

<0.001

 Mean daily dose,g g

1 (0 to 2)

0 (0 to 0)

1.9 (1.0 to 2.6)

<0.001

  1. aAPACHE, Acute Physiology and Chronic Health Evaluation; SAPS, Simplified Acute Physiology Score; SD, Standard deviation. bMechanical ventilation within first 24 hours of ICU admission. c24-hour urine output is <410 ml AND creatinine >133 μmol/L AND patient is not receiving chronic dialysis. dAPACHE III-J principal postoperative diagnosis. eA list of admission diagnosis with infection is provided in Additional file 1. fIndicates the presence of a given temperature at any time during intensive care unit stay. gMean daily dose calculated by dividing total dose by number by treatment days.
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Critical Care

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