Trigger mechanisms of secondary sclerosing cholangitis in critically ill patients

Table 2 Risk factors (prior to cholestasis) in 16 cases with SSC-CIP

No	Gender	Duration ICU (d)	MAP <65 mmHg	Ventilation	PaO₂/FiO₂ < 150	PEEP >10 cmH₂0	Transfusion units RBC	Colloidal solutions		Signs of tissue damage		SIRS	Pos. Cultures		TPN/ for d	High dose Propofol	AB
No	Gender	Duration ICU (d)	MAP <65 mmHg	Ventilation	PaO₂/FiO₂ < 150	PEEP >10 cmH₂0	Transfusion units RBC	HES 500 ml	GF 500 ml	CK (U/l)	Myoglobin (μg/l)	SIRS	BC	Other Isolates	TPN/ for d	High dose Propofol	AB
1	F	28	+	+	-	+12.0	18	7x	3x	n.a.	.n.a.	+	-	-	+/4	-	+
2	M	24	+	+	+	+11.0	12	-	-	5323	n.a.	+	-	Tr+	+/5	-	+
3	M	23	+	+	-	+12.0	20	4x	-	2348	3169	+	-	Tr+	+5	-	+
4	M	62	+	+	+	+10.0	4	8x	-	4920	2759	+	-	Tr+	+/6	+	+
5	M	70	+	+	-	+12.6	4	-	8x	4026	n.a.	+	-	-	+/6	-	+
6	M	48	+	+	+	+14.0	2	3x	2x	n.a.	n.a.	+	-	-	+/8	-	+
7	M	15	+	+	-	-	0	4x	-	n.a.	n.a.	+	-	Tr+	-	-	+
8	M	77	+	+	-	-	16	-	-	1244	n.a.	+	-	Tr+	-	-	+
9	M	82	+	+	-	-	26	1x	-	3645	29746	+	+	Ws+	+/2	-	+
10	F	54	+	+	+	+10.4	0	4x	-	536	n.a.	+	-	VC/U+	+/13	-	+
11	F	25	+	+	-	-	19	5x	-	345	n.a.	+	-	-	-	-	+
12	M	34	+	+	+	+14.0	10	-	1x	7250	7084	+	-	-	+/5	-	+
13	F	39	+	+	+	-	0	2x	-	1212	n.a.	+	-	Tr+	+/4	-	+
14	M	17	+	+	+	-	10	-	-	4975	n.a.	+	-	Tr+	-	-	+
15	M	13	+	+	-	-	4	1x	-	677	n.a.	+	-	Tr+	+/3	-	+
16	F	9	+	+	-	-	7	9x	1x	3166	n.a.	+	-	-	+/3	-	+

AB, antibiotics; BC, blood culture; CK, creatine kinase (normal range <170 U/l); d, days; GF, gelafusine; HES, hydroxyethyl starch; ICU, intensive care unit; MAP, mean arterial pressure; n.a., data not available; PEEP, positive end–expiratory pressure; RBC, red blood cells;, myoglobin (normal range <76 μg/l); SIRS, systemic inflammatory response syndrome; TPN, total parenteral nutrition/for n days; Tr, tracheal secretion; U, urine; VC, venous catheter tip; Ws, Wound swab.

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