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Table 3 Patient characteristics on ICU admission (day 1) in comparison between survivors and non-survivors

From: Strain echocardiography in septic shock – a comparison with systolic and diastolic function parameters, cardiac biomarkers and outcome

 

30 Days

P

90 Days

P

Survivors, n = 35

Non-survivors, n = 15

Survivors, n = 33

Non-survivors, n = 17

Demographics

Male sex, n (%)

24 (69)

7 (47)

0.12

18 (55)

9 (53)

0.54

Age, years, median (IQR)

65 (56 to 71)

75 (65 to 79)

0.01

64 (54 to 71)

72 (65 to 79)

0.02

Weight, kg, median (IQR)

74 (65 to 85)

68 (64 to 80)

0.42

72 (63 to 84)

70 (64 to 81)

0.86

Cardiac comorbidities, n (%)

15 (43)

9 (60)

0.23

14 (42)

10 (59)

0.17

Clinical data and cardiac biomarkers

Saps 3, median (IQR)

70 (59 to 76)

81 (70 to 88)

0.03

68 (59 to 76)

81 (70 to 88)

0.01

ICU length of stay, days, median (IQR)

115 (56 to 272)

93 (23 to 142)

0.13

168 (81 to 290)

78 (23 to 143)

0.02

Mechanical ventiltion, hours, median (IQR)

70 (0 to 240)

45 (9 to 135)

0.77

154 (19 to 245)

40 (2 to 118)

0.17

Sequential organ failure assessment score

10 (9 to 12)

12 (9 to 14)

0.62

10 (9 to 12)

11 (9 to 14)

0.61

PEEP, cmH2O

14 (10 to 16)

12 (10 to 15)

0.73

12 (10 to 15)

12 (10 to 15)

0.91

Pmax, cmH2O

28 (22 to 31)

32 (26 to 34)

0.18

28 (21 to 31)

32 (26 to 34)

0.21

Norepinephrine, ug/kg/min

0.09 (0.05 to 0.14)

0.11 (0.05 to 0.26)

0.50

0.09 (0.06 to 0.16)

0.08 (0.04 to 0.22)

0.95

Dobutamine, ug/kg/min

5.5 (3.1 to 8.2)

5.4 (4.7 to 11.3)

0.46

5.1 (3.1 to 8.8)

5.6 (4.8 to 10.4)

0.34

Fluids administered, ml/kg

127 (100 to 154)

89 (60 to 200)

0.34

131 (100 to 154)

90 (62 to 118)

0.15

Fluid balance, ml/kg

70 (33 to 95)

21 to 151)

0.99

71 (31 to 104)

59 (23 to 132)

0.96

Cardiac index, l/min/ m2

4.0 (3.3 to 5.0)

5.0 (4.6 to 5.4)

0.14

4.0 (3.2 to 5.1)

4.9 (4.3 to 5.4)

0.16

SVRI dyn × sec × cm−5/m2

1310 (1066 to 1582)

800 (600 to 852)

0.001

1,310 (1,062 to 1,585)

801 (600 to 1045)

0.002

NT-proBNP, ng/L

4230 (1410 to 10400)

7940 (2780 to 26400)

0.15

4,070 (1,400 to 8,510)

10,500 (2,860 to 30,700)

0.03

High sensitivity troponin T, ng/L

40 (24 to 119)

121 (39 to 530)

0.09

40 (26 to 236)

115 (42 to 348)

0.08

Echocardiography

Global longitudinal peak strain, %

−17.2 (−20.0 to (−13.0))

−15.0 (−19.7 to (−11.0))

0.34

−17.4 (−20.5 to −13.6)

−14.7 (−19.0 to −10.6)

0.11

Left ventricular ejection fraction, %

50 (42 to 57)

53 (37 to 59)

0.99

50 (44 to 58)

47 (36 to 56)

0.47

E/é

7.1 (5.9 to 11.0)

7.7 (5.4 to 10.7)

0.62

7.4 (6.0 to 11.7)

7.4 (5.7 to 9.0)

0.60

é, m/s

0.11 (0.08 to 0.18)

0.12 (0.83 to 0.16)

0.99

0.11 (0.08 to 0.16)

0.11 (0.08 to 0.16)

0.95

E, m/s

0.97 (0.79 to 1.07)

0.95 (0.61 to 1.07)

0.53

0.98 (0.79 to 1.08)

0.95 (0.60 to 1.11)

0.46

A, m/s

0.73 (0.57 to 0.92)

0.99 (0.845 to 1.20)

0.31

0.73 (0.59 to 0.89)

0.81 (0.47 to 1.48)

0.34

E/A

1.2 (1.0 to 1.7)

1.0 (0.8 to 1.2)

0.10

1.2 (1.0 to 1.7)

1.1 (0.9 to 1.2)

0.60

DT, ms

157 (140 to 197)

171 (105 to 200)

0.97

156 (140 to 199)

172 (126 to 204)

0.93

  1. Data are presented as median (IQR) or number (%), as appropriate. SAPS, simplified acute physiology score; Pmax, peak inspiratory pressure; PEEP, positive end-expiratory pressure; SVRI, systemic vascular resistance index; NT-proBNP, amino-terminal pro-brain natriuretic peptide; E: early mitral inflow; é: early mitral tissue Doppler velocity; A: late mitral inflow; DT: early mitral inflow deceleration time.