Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients

Kalfon, Pierre; Le Manach, Yannick; Ichai, Carole; Bréchot, Nicolas; Cinotti, Raphaël; Dequin, Pierre-François; Riu-Poulenc, Béatrice; Montravers, Philippe; Annane, Djilalli; Dupont, Hervé; Sorine, Michel; Riou, Bruno

doi:10.1186/s13054-015-0851-7

Critical Care

Table 4 Comparison of outcome and blood glucose metrics in matched groups^a

From: Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients

		Matching for moderate hypoglycemia			Matching for severe hypoglycemia
Variables		No hypoglycemia	Moderate hypoglycemia	P -value	No hypoglycemia	Severe hypoglycemia	P -value
Variables		(n =640)	(n =640)	P -value	(n =366)	(n =199)	P -value
Probability of death		0.28 (0.19)	0.28 (0.18)	0.66	0.32 (0.19)	0.35 (0.19)	0.12
Outcomes
	RRT-free days	28 (21 to 28)	28 (7 to 28)	0.06	28 (0 to 28)	24 (0 to 28)	<0.001
	Catecholamine-free days	25 (17 to 27)	24 (2 to 27)	<0.001	24 (0 to 26)	18 (0 to 25)	<0.001
	Mechanical ventilation to free days	20 (0 to 25)	15 (0 to 23)	<0.001	17 (0 to 24)	18 (0 to 25)	<0.001
	ICU-free days	19 (0 to 24)	13 (0 to 22)	<0.001	17 (0 to 24)	0 (0 to 28)	<0.001
	Mortality 28 days	137 (21%)	151 (24%)	0.38	102 (28%)	75 (38%)	0.017
	Mortality 90 days	176 (27%)	213 (33%)	0.029	131 (35%)	106 (53%)	<0.001
Blood glucose metrics
	Mean blood glucose	7.2 (1.6)	6.6 (1.1)	<0.001	7.3 (1.6)	6.8 (1.5)	<0.001
	Blood glucose CV	0.21 (0.09)	0.28 (0.09)	<0.001	0.22 (0.09)	0.33 (0.12)	<0.001
	Insulin dose (IU/day)	22 (6 to 43)	35 (5 to 59)	<0.001	23 (7 to 41)	35 (19 to 56)	<0.001
		Matching for multiple hypoglycemic events
Variables		No hypoglycemia	Multiple hypoglycemic	P -value
Variables		(n =445)	(n =234)	P -value
Probability of death		0.32 (0.20)	0.32 (0.19)	0.81
Outcomes
	RRT-free days	28 (0 to 28)	28 (0 to 28)	0.06
	Catecholamine-free days	24 (0 to 26)	19 (0 to 25)	0.001
	Mechanical ventilation to free days	18 (0 to 24)	5 (0 to 18)	<0.001
	ICU-free days	17 (0 to 24)	1 (0 to 17)	<0.001
	Mortality 28 days	115 (26%)	64 (27%)	0.71
	Mortality 90 days	141 (32%)	108 (46%)	<0.001
Blood glucose metrics
	Mean blood glucose	7.0 (1.5)	6.7 (1.0)	<0.001
	Blood glucose CV	0.24 (0.10)	0.31 (0.09)	<0.001
	Insuline dose (IU/day)	26 (8 to 49)	41 (22 to 63)	<0.001

^aData are expressed as mean (standard deviation), median (25th to 75th interquartile range) and number (%). ICU, Intensive care unit; RRT, Renal replacement therapy; CV, Coefficient of variation.

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