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Table 4 Comparison of outcome and blood glucose metrics in matched groupsa

From: Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients

  Matching for moderate hypoglycemia Matching for severe hypoglycemia
Variables No hypoglycemia Moderate hypoglycemia P -value No hypoglycemia Severe hypoglycemia P -value
(n =640) (n =640) (n =366) (n =199)
Probability of death 0.28 (0.19) 0.28 (0.18) 0.66 0.32 (0.19) 0.35 (0.19) 0.12
Outcomes       
  RRT-free days 28 (21 to 28) 28 (7 to 28) 0.06 28 (0 to 28) 24 (0 to 28) <0.001
  Catecholamine-free days 25 (17 to 27) 24 (2 to 27) <0.001 24 (0 to 26) 18 (0 to 25) <0.001
  Mechanical ventilation to free days 20 (0 to 25) 15 (0 to 23) <0.001 17 (0 to 24) 18 (0 to 25) <0.001
  ICU-free days 19 (0 to 24) 13 (0 to 22) <0.001 17 (0 to 24) 0 (0 to 28) <0.001
  Mortality 28 days 137 (21%) 151 (24%) 0.38 102 (28%) 75 (38%) 0.017
  Mortality 90 days 176 (27%) 213 (33%) 0.029 131 (35%) 106 (53%) <0.001
Blood glucose metrics       
  Mean blood glucose 7.2 (1.6) 6.6 (1.1) <0.001 7.3 (1.6) 6.8 (1.5) <0.001
  Blood glucose CV 0.21 (0.09) 0.28 (0.09) <0.001 0.22 (0.09) 0.33 (0.12) <0.001
  Insulin dose (IU/day) 22 (6 to 43) 35 (5 to 59) <0.001 23 (7 to 41) 35 (19 to 56) <0.001
  Matching for multiple hypoglycemic events    
Variables No hypoglycemia Multiple hypoglycemic P -value    
(n =445) (n =234)
Probability of death 0.32 (0.20) 0.32 (0.19) 0.81    
Outcomes       
  RRT-free days 28 (0 to 28) 28 (0 to 28) 0.06    
  Catecholamine-free days 24 (0 to 26) 19 (0 to 25) 0.001    
  Mechanical ventilation to free days 18 (0 to 24) 5 (0 to 18) <0.001    
  ICU-free days 17 (0 to 24) 1 (0 to 17) <0.001    
  Mortality 28 days 115 (26%) 64 (27%) 0.71    
  Mortality 90 days 141 (32%) 108 (46%) <0.001    
Blood glucose metrics       
  Mean blood glucose 7.0 (1.5) 6.7 (1.0) <0.001    
  Blood glucose CV 0.24 (0.10) 0.31 (0.09) <0.001    
  Insuline dose (IU/day) 26 (8 to 49) 41 (22 to 63) <0.001    
  1. aData are expressed as mean (standard deviation), median (25th to 75th interquartile range) and number (%). ICU, Intensive care unit; RRT, Renal replacement therapy; CV, Coefficient of variation.