| |
Matching for moderate hypoglycemia
|
Matching for severe hypoglycemia
|
|---|
|
Variables
|
No hypoglycemia
|
Moderate hypoglycemia
|
P
-value
|
No hypoglycemia
|
Severe hypoglycemia
|
P
-value
|
|---|
|
(n =640)
|
(n =640)
|
(n =366)
|
(n =199)
|
|---|
|
Probability of death
|
0.28 (0.19)
|
0.28 (0.18)
|
0.66
|
0.32 (0.19)
|
0.35 (0.19)
|
0.12
|
|
Outcomes
| | | | | | |
| |
RRT-free days
|
28 (21 to 28)
|
28 (7 to 28)
|
0.06
|
28 (0 to 28)
|
24 (0 to 28)
|
<0.001
|
| |
Catecholamine-free days
|
25 (17 to 27)
|
24 (2 to 27)
|
<0.001
|
24 (0 to 26)
|
18 (0 to 25)
|
<0.001
|
| |
Mechanical ventilation to free days
|
20 (0 to 25)
|
15 (0 to 23)
|
<0.001
|
17 (0 to 24)
|
18 (0 to 25)
|
<0.001
|
| |
ICU-free days
|
19 (0 to 24)
|
13 (0 to 22)
|
<0.001
|
17 (0 to 24)
|
0 (0 to 28)
|
<0.001
|
| |
Mortality 28 days
|
137 (21%)
|
151 (24%)
|
0.38
|
102 (28%)
|
75 (38%)
|
0.017
|
| |
Mortality 90 days
|
176 (27%)
|
213 (33%)
|
0.029
|
131 (35%)
|
106 (53%)
|
<0.001
|
|
Blood glucose metrics
| | | | | | |
| |
Mean blood glucose
|
7.2 (1.6)
|
6.6 (1.1)
|
<0.001
|
7.3 (1.6)
|
6.8 (1.5)
|
<0.001
|
| |
Blood glucose CV
|
0.21 (0.09)
|
0.28 (0.09)
|
<0.001
|
0.22 (0.09)
|
0.33 (0.12)
|
<0.001
|
| |
Insulin dose (IU/day)
|
22 (6 to 43)
|
35 (5 to 59)
|
<0.001
|
23 (7 to 41)
|
35 (19 to 56)
|
<0.001
|
| |
Matching for multiple hypoglycemic events
| | | |
|
Variables
|
No hypoglycemia
|
Multiple hypoglycemic
|
P
-value
| | | |
|
(n =445)
|
(n =234)
|
|
Probability of death
|
0.32 (0.20)
|
0.32 (0.19)
|
0.81
| | | |
|
Outcomes
| | | | | | |
| |
RRT-free days
|
28 (0 to 28)
|
28 (0 to 28)
|
0.06
| | | |
| |
Catecholamine-free days
|
24 (0 to 26)
|
19 (0 to 25)
|
0.001
| | | |
| |
Mechanical ventilation to free days
|
18 (0 to 24)
|
5 (0 to 18)
|
<0.001
| | | |
| |
ICU-free days
|
17 (0 to 24)
|
1 (0 to 17)
|
<0.001
| | | |
| |
Mortality 28 days
|
115 (26%)
|
64 (27%)
|
0.71
| | | |
| |
Mortality 90 days
|
141 (32%)
|
108 (46%)
|
<0.001
| | | |
|
Blood glucose metrics
| | | | | | |
| |
Mean blood glucose
|
7.0 (1.5)
|
6.7 (1.0)
|
<0.001
| | | |
| |
Blood glucose CV
|
0.24 (0.10)
|
0.31 (0.09)
|
<0.001
| | | |
| |
Insuline dose (IU/day)
|
26 (8 to 49)
|
41 (22 to 63)
|
<0.001
| | | |
-
aData are expressed as mean (standard deviation), median (25th to 75th interquartile range) and number (%). ICU, Intensive care unit; RRT, Renal replacement therapy; CV, Coefficient of variation.
