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Table 2 Blood glucose metricsa

From: Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients

Variables No hypoglycemia Moderate hypoglycemia Severe hypoglycemia Multiple hypoglycemic events
(n =1,474) (n =874) (n =253) (n =482)
Initial blood glucose, mmol/L 8.9 (4.0) 9.6 (4.6)b 9.8 (5.5)b 9.7 (4.2)b
Mean morning blood glucose, mmol/L 7.2 (2.3) 6.8 (1.6)b 6.8 (1.8)b 6.7 (1.8)b
Mean blood glucose, mmol/L 7.2 (1.7) 6.7 (1.2)b 6.8 (1.5)b 6.6 (1.2)b
Maximum blood glucose, mmol/L 11.3 (1.4) 12.8 (4.1)b 14.6 (5.1)bc 14.2 (4.9)b
Minimum Blood glucose, mmol/L 4.6 (1.4) 2.9 (0.3) 1.7 (0.4) 2.2 (0.6)
Blood glucose standard deviation, mmol/L 1.5 (1.0) 2.0 (1.0)b 2.4 (1.3)bc 2.2 (1.1)b
Blood glucose CV 0.20 (0.15 to 0.26) 0.27 (0.22 to 0.34)b 0.32 (0.25 to 0.39)bc 0.31 (0.25 to 0.38)b
Blood glucose CV >0.20 715/1,428 (50%) 735/873 (84%)b 235/253 (93%)bc 452/479 (94%)b
Total insulin dose, IU 121 (38 to 344) 348 (123 to 801)b 442 (129 to 986)b 534 (201 to 1109)b
Daily insulin dose, IU/day 19 (4 to 41) 34 (15 to 58)b 35 (17 to 59)b 38 (20 to 61)b
Days with insulin 5 (3 to 11) 9 (4 to 17)b 10 (5 to 20)bc 12 (6 to 22)b
Number of blood glucose measurements 28 (16 to 56) 44 (24 to 80)b 52 (28 to 104)bc 50 (32 to 108)b
Number of moderate hypoglycemia   2 (1 to 3) 3 (1 to 6) 4 (3 to 6)
Number of severe hypoglycemia 1 (1 to 2) 0 (0 to 1)
Number of hypoglycemic events (any type) 2 (1 to 3) 5 (3 to 8) 4 (3 to 7)
Hypoglycemic events (any type) ≥3 286 (33%) 197 (77%) 482 (100%)
  1. aData are expressed as mean (standard deviation), median (25th to 75th interquartile range) and number (%). CV, Coefficient of variation. b P <0.05 vs. no hypoglycemia group; c P <0.05 vs. moderate hypoglycemia group (only for severe hypoglycemia group). The number of hypoglycemic events and the minimum blood glucose were not tested for statistical significance.