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Table 3 Whole-body protein kinetics

From: Short-term amino acid infusion improves protein balance in critically ill patients

 

Breakdown

Synthesis

Balance

Splanchnic extraction

Oxidation

Q1 effect AA (n =13)

     
 

First basal

60 (32 to 99)

58 (34 to 90)

−4 (−21 to 5)

0.4 (0.2 to 0.6)

11 (5 to 24)

 

First AA

62 (25 to 82)

65 (40 to 87)

7 (−10 to 14)

0.2 (−0.1 to 0.9)

11 (4 to 21)

 

P-value

0.92

0.007

0.001

0.037

0.47

Q2 time effect basal (n =10)

     
 

First basal

59 (32 to 99)

54 (34 to 90)

−5 (−21 to 5)

0.4 (0.2 to 0.6)

9 (5 to 21)

 

Second basal

60 (35 to 95)

59 (29 to 95)

−5 (−18 to 5)

0.3 (−0.1 to 0.9)

11 (5 to 26)

 

P-value

0.17

0.45

0.80

0.31

0.20

Q3 time effect AA (n =7)

     
 

Change from first basal to AA

3 (−24 to 12)

12 (−13 to 21)

10 (9 to 16)

−0.1 (−0.4 to 0.2)

0 (−2 to 6)

 

Change from second basal to AA

−1 (−22 to 6)

4 (−11 to 25)

12 (4 to 25)

0 (−0.1 to 0.5)

−1 (−16 to 3)

 

P-value

0.40

0.50

0.50

0.14

0.40

  1. The data represent whole-body protein turnover rates of the three patient cohorts to answer the three research questions (Q1 to Q3), expressed as micromolar phenylalanine per kilogram of body weight per hour, except for the splanchnic extraction, which is shown as a fraction. Question 1: Do extra parenteral amino acids (AA) during the first week in the intensive care unit (ICU) modulate whole-body protein kinetics? Question 2: Do baseline protein kinetics change during early ICU treatment? Question 3: Are the effects of extra parenteral amino acids maintained after a few days. P-values indicate statistically significant difference for question 1 between amino acid supplementation (AA) and basal; for question 2, between basal measurements on the 2 study days; and for question 3, between the change from basal to supplementation on study days 1 and 2, respectively (Wilcoxon signed-rank test).