Mechanical ventilation modes for respiratory distress syndrome in infants: a systematic review and network meta-analysis

Wang, Changsong; Guo, Libo; Chi, Chunjie; Wang, Xiaoyang; Guo, Lei; Wang, Weiwei; Zhao, Nana; Wang, Yibo; Zhang, Zhaodi; Li, Enyou

doi:10.1186/s13054-015-0843-7

Critical Care

Table 1 Characteristics of the randomized controlled trials of 16 ventilation modes for infants with respiratory distress syndrome

From: Mechanical ventilation modes for respiratory distress syndrome in infants: a systematic review and network meta-analysis

Reference	Ventilation modes	Number of patients	Birth weight, grams	Gestational age, weeks	Quality assessment, Jadad scale	Diagnosis	Result
Reference	Ventilation modes	Number of patients	Birth weight, grams	Gestational age, weeks	Quality assessment, Jadad scale	Diagnosis	Mortality	ICU length of stay, days	Pneumothorax, number	Hospital length of stay, days	BPD, number	IVH of at least grade III, number	PDA, number
Singh et al. [6]	HFOV vs. SIMV	110	1,398 ± 321/1,393 ± 320	32.0 ± 2.4/31.9 ± 2.5	7	RDS	Yes	No	No	10.3 ± 7.1/10.3 ± 7.1	No	No	No
Lista et al. [7]	HFOV vs. A/C + VG	40	1,015 ± 200/1,006 ± 185	27.3 ± 2/27.4 ± 2	6	RDS	Yes	No	No	No	No	1/1	No
Duman et al. [10]	A/C + VG vs. A/C	45	1,055.8 ± 236.3/975.5 ± 294.3	27.8 ± 1.7/27.6 ± 2.1	5	RDS	Yes	No	2/2	47.5 ± 22.9/54.2 ± 22.5	3/7	3/7	14/14
Sinha et al. [11]	V-C vs. TCPL	50	1,793 ± 513/1,762 ± 503	31.2 ± 2.1/31.2 ± 2.5	5	RDS	Yes	No	0/3	No	1/6	No	4/6
Guven et al. [12]	SIMV + VG vs. SIMV	72	1,352.57 ± 373.83/1,275.00 ± 311.63	29.40 ± 2.12/29.17 ± 1.84	7	RDS	Yes	No	No	45.50 ± 31.43/40.00 ± 31.24	2/9	No	No
Salvo et al. [27]	HFOV vs. TCPL	88	869 ± 266/913 ± 224	26.4 ± 2.2/26.5 ± 3.2	7	RDS	Yes	21 ± 12/36 ± 23	No	53 ± 21/77 ± 33	No	3/6	No
Castoldi et al. [28]	A/C + VG + RM vs A/C + VG	20	747 ± 233/737 ± 219	25 ± 2/25 ± 2	6	RDS	Yes	No	No	No	0/2	No	6/4
Carlo et al. [29]	TCPL vs. HFJV	40	1,470 ± 350/1408 ± 240	30 ± 2/30 ± 2	5	RDS	Yes	No	6/3	No	4/3	No	No
HiFO Study Group [30]	HFOV vs. TCPL	176	1,732 ± 979/1,744 ± 853	31 ± 4/31 ± 4	7	RDS	Yes	No	No	No	No	No	24/28
Pardou et al. [31]	HFFIV vs. TCPL	22	1,454 ± 197/1,194 ± 23	29.8 ± 1.5/29.2 ± 1.96	5	RDS	Yes	No	5/3	No	No	1/2	No
Wiswell et al. [32]	TCPL vs. HFJV	73	930 ± 220/961 ± 314	26.6 ± 2.1/26.9 ± 2.9	7	RDS	Yes	No	7/3	75.9 ± 18.7/66.1 ± 33.8	No	No	No
Gerstmann et al. [33]	HFOV vs. TCPL	125	1,560 ± 460/1,460 ± 470	30.8 ± 2.2/30.1 ± 2.7	6	RDS	Yes	No	No	44.0 (30.6,52.6)/46.9 (39.2,56.0)^a	No	2/6	20/19
Beresford et al. [34]	PTV vs. TCPL	386	1,336 (1,000-1,997)/1,320 (1,006-1,996)^c	29 (25-36)/29 (25-34)^c	7	RDS	Yes	No	20/21	No	No	11/13	No
Baumer [35]	PTV vs. IMV	924	1,097 ± 327/1,123 ± 345	27.8 ± 2.0/27.8 ± 2.1	6	RDS	Yes	No	62/47	No	No	No	No
Lista et al. [36]	PSV + VG vs. PSV	53	1,125 ± 370/1,197 ± 333	28.5 ± 2/29.4 ± 1.6	5	RDS	Yes	No	0/3	No	3/4	No	No
Nafday et al. [37]	SIMV vs. PSV + VG	34	1,055 ± 77/1,198 ± 108	27.4 ± 0.5/27.9 ± 0.6	6	RDS	Yes	No	No	No	No	6/3	5/4
Dani et al. [38]	HFOV vs. PSV + VG	25	1,126 ± 170/1,075 ± 313	28.3 ± 1.5/28.0 ± 1.3	6	RDS	Yes	66.2 ± 19.9/62.8 ± 24.2	No	66.2 ± 19.9/62.8 ± 24.2	4/3	No	11/9
Singh et al. [39]	V-C vs. TCPL	109	985/976^b	27.1/27.2^b	7	RDS	Yes	No	2/4	No	No	5/5	17/15
Liu et al. [40]	SIPPV + VG vs. HFOV vs. IMV	84	1,702 ± 701/1,813 ± 732/1,902 ± 603	31.5 ± 3.6/30.2 ± 4.8/32.3 ± 3.4	5	RDS	Yes	No	No	No	No	No	No
Sun et al. [41]	HFOV vs. SIMV + PSV	356	1,129 ± 199/1,117 ± 241	29.3 ± 2.5/29.5 ± 2.3	7	RDS	Yes	No	10/21	27.0 ± 20.2/31.6 ± 21.7	13/28	No	No

‘Yes’ represents the existence of a result, and ‘No’ refers to no result. ^aMedian (95% confidence limits), ^bmean, ^cmedian (interquartile range). A/C, assist-control ventilation; A/C + VG, assist-control plus volume-guarantee ventilation; A/C + VG + RM, assist-control plus volume-guarantee ventilation with recruitment maneuver; BDP, bronchopulmonary dysplasia; HFFIV, high-frequency flow interrupted ventilation; HFJV, high-frequency jet ventilation; HFOV, high-frequency oscillatory ventilation; ICU, intensive care unit; IMV, intermittent mandatory ventilation; IVH, intraventricular hemorrhage; PDA, patent ductus arteriosus; PSV, pressure support ventilation; PSV + VG, pressure support ventilation with volume-guarantee ventilation; PTV, patient-triggered ventilation; RDS, respiratory distress syndrome; SIMV, synchronized intermittent mechanical ventilation; SIMV + PSV, synchronized intermittent mechanical ventilation with pressure support ventilation; SIMV + VG, synchronized intermittent mechanical ventilation with volume-guarantee ventilation; SIPPV + VG, synchronized intermittent positive pressure ventilation plus volume-guarantee ventilation; TCPL, time-cycled pressure-limited ventilation; V-C, volume-controlled (through adjusting the delivered tidal volume).

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