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Table 4 Clinical relevance of the NF-κB gene polymorphisms in patients with major trauma

From: Identification of haplotype tag single nucleotide polymorphisms within the nuclear factor-κB family genes and their clinical relevance in patients with major trauma

SNPs Genotype Number Age, years Sex, male/female, n ISS Sepsis, n (%) MOD score
rs28362491 II 245 40.5 ± 12.4 145/100 22 ± 10.3 108 (44.1) 5.0 ± 2.3
  ID 386 42 ± 13.6 306/80 21.9 ± 8.6 156 (40.4) 4.9 ± 2.1
  DD 122 40.2 ± 13.2 98/24 24 ± 10.5 47 (38.5) 4.9 ± 2.5
rs4648068 AA 231 39.6 ± 12.5 192/39 22.0 ± 10.5 98 (42.4) 4.9 ± 2.0
  AG 370 42.5 ± 13.8 294/76 22.1 ± 8.5 153 (41.4) 5.1 ± 2.4
  GG 151 40.4 ± 13.2 116/35 23.2 ± 10.3 56 (37.1) 4.5 ± 1.7
rs7119750 CC 280 40.8 ± 13.30 222/58 22.3 ± 9.9 118 (42.1) 5.0 ± 2.3
  CT 374 40.9 ± 13.2 306/68 22.5 ± 9.4 154 (41.2) 4.9 ± 2.2
  TT 94 43.9 ± 13.9 72/22 21.3 ± 8.9 38 (40.4) 5.1 ± 2.2
rs842647 GG 551 40.7 ± 13.0 438/113 22.4 ± 9.9 228 (41.4) 5.0 ± 2.3
  GA 167 42.8 ± 14.4 135/32 22.1 ± 7.9 70 (41.9) 4.8 ± 2.0
  AA 15 43.2 ± 16.6 14/1 20.5 ± 10.2 2 (13.3) 3.1 ± 1.1
P-value       a1 a2
  1. ISS, injury severity score; MOD, multiple organ dysfunction; a, recessive effect (variant homozygotes versus heterozygotes + wild-type homozygotes) as analyzed by one-way analysis of variance. a1, P = 0.024; a2, P = 0.013.