Hydroxyethyl starch versus other fluids for non-septic patients in the intensive care unit: a meta-analysis of randomized controlled trials

He, Bin; Xu, Bo; Xu, Xiaoxing; Li, Lixia; Ren, Rongrong; Chen, Zhiyu; Xiao, Jian; Wang, Yingwei; Xu, Bin

doi:10.1186/s13054-015-0833-9

Critical Care

Table 1 Characteristics of articles included, patient diagnosis, number of participants, interventions, and related details of reports

From: Hydroxyethyl starch versus other fluids for non-septic patients in the intensive care unit: a meta-analysis of randomized controlled trials

Author, year	Diagnosis	Patients (n)	Intervention		Control		Total dose of hydroxyethyl starch (HES)	Volume expansion goals	Intervention period	PD or CA
Author, year	Diagnosis	Patients (n)	Study fluids	n1	Control fluids n2		Total dose of hydroxyethyl starch (HES)	Volume expansion goals	Intervention period	PD or CA
Ley, 1990 [22]	After cardiac surgery	21	6% HES 450/0.7 11		Normal saline	10	Up to 1.5 L	CI >2.0 L/min/m²	NS	PD
Beards,1994 [36]	Hypovolemia	25	6% HES 450/0.7 13		Gelatin	12	500 mL bolus	NS	15 to 30 minutes	PD
Van der Linden, 2005 [23]	After cardiac surgery	132	6% HES 130/0.4	64	Gelatin	68	Maximum 50 mL/kg/day	PAOP, 8 to 15 mmHg	NS	PD
								CI >2.5 L/min/m²
								Urine >0.5 mL/kg/h
Chen, 2006 [37]	Burn	66	6% HES 130/0.4	33	Plasma	33	2328 ± 271 mL	CVP 7 to 14 mmHg	48 h	CA
Chen, 2006 [37]	Burn	66	6% HES 130/0.4	33	Plasma	33	2328 ± 271 mL	Urine >0.5 mL/kg/h	48 h	CA
Mahmood, 2007 [24]	After aortic aneurysm surgery	62	6% HES 130/0.4	21	Gelatin	20	Surgery, 3 ml/kg/h	MAP >85 mmHg	Surgery and ICU	PD
Mahmood, 2007 [24]	After aortic aneurysm surgery	62	6% HES 200/0.62	21	Gelatin	20	CU, as needed	CVP 8 to 10 mmHg	Surgery and ICU	PD
Godet, 2008 [25]	After abdominal aortic surgery	65	6% HES 130/0.4	32	Gelatin	33	As needed	Doctor’s judgement	Surgery and 6 d in ICU	PD
Mukhtar, 2009 [26]	After transplantation surgery	40	6% HES 130/0.4	20	Albumin	20	Maximum 50 mL/kg/day	CVP, 5 to 7 mmHg	Surgery and 4 d in ICU	PD
Ooi, 2009 [27]	After cardiac surgery	90	6% HES 130/0.4	45	Gelatin	45	As needed	CVP, 10 to 14 mmHg	NS	PD
Schramko, 2009 [28]	After cardiac surgery	45	6% HES 130/0.4	15	Albumin	15	NS	PAWP, 10 to 14 mmHg	NS	PD
Schramko, 2009 [28]	After cardiac surgery	45	6% HES 200/0.62	15	Albumin	15	NS	CI >2.0 L/min/m²	NS	PD
Choi, 2010 [29]	After abdominal aortic surgery	36	6% HES 130/0.4	18	Albumin	18	Maximum 20 mL/kg in ICU	PAOP, 10 to 14 mmHg	NS	PD
								CI >2.0 L/min/m²
								Urine >0.5 mL/kg/h
Gondos, 2010 [38]	Hypovolemia	106	6% HES 130/0.4	26	RL	28	10 mL/kg	NS	NS	PD
					Gelatin	25
					Albumin	27
Heradstveit, 2010 [39]	After cardiac arrest	19	6% HES 200/0.5	10	RL	9	maximum 500 mL/24 h	MAP >60 mmHg	Observation period	PD
								HR, 60 to 100/min
								CVP, 8 to 12 mmHg
Inal, 2010 [40]	Hypovolemia	30	6% HES 130/0.4	15	Gelatin	15	500 mL	NS	NS	PD
Schramko, 2010 [30]	After cardiac surgery	45	6% HES 130/0.4	15	RL	15	28 mL/kg	PCWP, 10 to15 mmHg	16 to 20 h in ICU	PD
Schramko, 2010 [30]	After cardiac surgery	45	6% HES 130/0.4	15	Gelatin	15	28 mL/kg	CI > 2.0 L/min/m²	16 to 20 h in ICU	PD
Du, 2011 [41]	Acute pancreatitis	41	6% HES 130/0.4	20	RL	21	as needed	CVP, 8 to 15 mmHg	8 d in hospital	CA
							1:3 with saline	Urine >0.5 mL/kg/h
							1:3 with saline	SBP >90 mmHg
James, 2011 [42]	Trauma	109	6% HES 130/0.4	56	Normal saline	53	500 mL boluses	CVP >12 mmHg	15 minutes	PD
James, 2011 [42]	Trauma	109	6% HES 130/0.4	56	Normal saline	53	500 mL boluses	Urine >0.5 mL/kg/h	15 minutes	PD
Lee, 2011 [31]	After cardiac surgery	106	6% HES 130/0.4	53	Crystalloid	53	Maximum 50 mL/kg/d	CI >2.2 L/min/m²	NS	PD
								SvO2 > 60%
								Urine >0.5 mL/kg/h
Yang, 2011 [32]	After hepatectomy	81	6% HES 130/0.4	26	RL	25	1,000 mL/d*3d	CVP, 5 to 9 mmHg	5 d	CA
Yang, 2011 [32]	After hepatectomy	81	6% HES 130/0.4	26	Albumin	30	500 mL/d*2d	MAP, 60 to 80 mmHg	5 d	CA
Myburgh, 2012 [6]	Non-septic patients	4720	6% HES 130/0.4	2337	Normal saline	2383	500 mL bolus, maximum 50 mL/kg/d	NS	90 d	CA
Alavi, 2012 [33]	After cardiac surgery	92	6% HES 130/0.4	32	RL	29	As needed	CVP, 7 to 14 mmHg	Surgery and ICU	PD
Alavi, 2012 [33]	After cardiac surgery	92	6% HES 130/0.4	32	Gelatin	31	As needed	CVP, 7 to 14 mmHg	Surgery and ICU	PD
Nagpal D, 2012 [34]	After cardiac surgery	70	6% HES 130/0.4	35	Crystalloid	35	1 to 3.0 L/d	NS	NS	PD
Kimenai, 2013 [35]	After cardiac surgery	60	6% HES 130/0.4	30	Gelatin	30	NS	NS	NS	PD

RL, Ringer lactate; n, number of overall patients; n1, number of patients in intervention group; n2 number of patients in control group; NS, not stated; CI, cardiac index; PAOP, pulmonary artery occlusive pressure; CVP, central venous pressure; MAP, mean arterial pressure; PAWP, pulmonary artery wedge pressure; HR, heart rate; PCWP, pulmonary capillary wedge pressure; SBP systolic blood pressure; SvO2, mixed venous oxygen saturation; PD, published data; CA, connected with author successfully.

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