Copeptin levels are associated with organ dysfunction and death in the intensive care unit after out-of-hospital cardiac arrest

Table 2 Results of multi-variable regression analysis of factors associated with a poor long-term neurological outcome

Variables	Risk category	Model 1 (with cortisol)	P value	Model 2 (with copeptin)	P value
Variables	Risk category	OR (95% CI)	P value	OR (95% CI)	P value
Age	Increase/year	1.05 (1.03-1.08)	<0.001	1.05 (1.02-1.08)	<0.001
Witnessed arrest	Yes	0.5 (0.15-1.5)	0.210	0.5 (0.14-1.5)	0.194
Initial rhythm	Not shockable	4.5 (2.2-9.3)	<0.001	4.5 (2.2-9.3)	<0.001
Time to ROSC	Increase/minute	1.08 (1.04-1.12)	<0.001	1.07 (1.03-1.12)	<0.001
Adrenaline	Yes	2.5 (1.2-5.2)	0.019	2.4 (1.12-5.1)	0.024
Therapeutic hypothermia	Yes	0.7 (0.3-1.5)	0.321	0.7 (0.3-1.5)	0.33
Cortisol	Increase/SD	1.1 (0.8-1.5)	0.535	-	-
Copeptin	Increase/SD	-	-	1.2 (0.8-1.8)	0.340

CI, confidence interval; OR, odds ratio; ROSC, return of spontaneous circulation; SD, standard deviation.

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