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Table 4 Optimum thresholds and respective test accuracy parameters for predicting (a) acute traumatic coagulopathy (ATC) defined as INR >1.2 and (b) massive transfusion (MT) (defined as ≥10 units of PRBC)

From: Detection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: an international prospective validation study

Test parameter Optimum threshold Detection rate False positive rate PPV NPV
(a)  
EXTEM CA5 ≤37 (34-39) 66.3 (55.1-76.3) 18.8 (15.9-21.9) 29.9 (23.4-37.1) 95.2 (93.2-96.8)
FIBTEM CA5 ≤8 (5-8) 67.5 (55.9-77.8) 20.7 (17.7-23.9) 26.9 (20.8-33.8) 95.6 (93.5-97.1)
Fibrinogen ≤1.61 (1.36-1.9) 73.6 (63.0-82.4) 11.5 (9.2-14.1) 45.1 (36.7-53.6) 96.3 (94.5-97.7)
Platelet count ≤199 (128-199) 61.7 (46.4-75.5) 29.9 (26.6-33.4) 11.9 (8.1-16.7) 96.5 (94.6-97.9)
(b)
EXTEM CA5 ≤40 (32-40) 72.7 (57.2-85.0) 31.3 (28.0-34.8) 12.2 (8.5-16.8) 97.7 (96.0-98.8)
FIBTEM CA5 ≤9 (6-9) 77.5 (61.5-89.2) 32.8 (29.4-36.4) 11.4 (7.9-15.8) 98.2 (96.6-99.2)
Fibrinogen ≤1.90 (1.39-2.18) 77.8 (62.9-88.8) 29.7 (26.4-30.1) 14.0 (9.9-18.9) 98.1 (96.5-99.1)
INR ≥1.13 (1.0-1.16) 70.2 (55.1-82.7) 19.0 (16.2-22.1) 19.2 (13.6-25.9) 97.7 (96.2-98.7)
Platelet count ≤174 (159-182) 52.8 (41.9-63.5) 14.8 (12.2-17.7) 32.2 (24.7-40.4) 93.1 (90.8-95.0)
  1. INR, international normalized ratio; PRBC, packed red blood cells; PPV, positive predictive value; NPV, negative predictive value; CA5, clot amplitude after 5 minutes.