An observational study of surface versus endovascular cooling techniques in cardiac arrest patients: a propensity-matched analysis

Oh, Sang Hoon; Oh, Joo Suk; Kim, Young-Min; Park, Kyu Nam; Choi, Seung Pill; Kim, Gi Woon; Jeung, Kyung Woon; Jang, Tae Chang; Park, Yoo Seok; Kyong, Yeon Young

doi:10.1186/s13054-015-0819-7

Critical Care

Table 3 Independent predictors for poor neurological outcome and hospital discharge in the unmatched cohort

From: An observational study of surface versus endovascular cooling techniques in cardiac arrest patients: a propensity-matched analysis

	Poor neurological outcome						Hospital mortality
	OR	95% CI	P value	Adjusted OR	95% CI	P value	OR	95% CI	P value	Adjusted OR	95% CI	P value
Method
Surface cooling	1.58	1.15 to 2.19	0.01	1.46	0.81 to 2.63	0.21	1.06	0.78 to 1.44	0.73	0.78	0.50 to 1.21	0.26
Demographic characteristics
Male	0.50	0.35 to 0.72	<0.01	0.63	0.37 to 1.06	0.08	0.56	0.41 to 0.76	<0.01	0.67	0.47 to 0.96	0.03
Age	1.04	1.03 to 1.05	<0.01	1.04	1.02 to 1.06	<0.01	1.02	1.01 to 1.03	<0.01	1.02	1.00 to 1.03	0.01
≥57 years old	3.04	2.20 to 4.20	<0.01				1.92	1.44 to 2.57	<0.01
Underlying disease
Ischemic heart disease	0.77	0.50 to 1.20	0.25				0.85	0.55 to 1.31	0.46
Cerebrovascular disease	2.30	0.88 to 6.03	0.09				1.96	0.98 to 3.96	0.06
Hypertension	1.63	1.16 to 2.28	0.01	1.29	0.72 to 2.31	0.40	1.29	0.95 to 1.73	0.10
Diabetes mellitus	2.59	1.67 to 4.00	<0.01	1.68	0.86 to 3.29	0.13	1.94	1.39 to 2.72	<0.01	1.54	1.02 to 2.33	0.04
Lung disease	5.02	1.79 to 14.09	<0.01	3.09	0.82 to 11.65	0.10	1.22	0.69 to 2.17	0.49
Renal disease	5.13	1.83 to 14.41	<0.01	1.48	0.43 to 5.13	0.54	2.11	1.20 to 3.72	0.01	1.09	0.56 to 2.15	0.80
CPR variables
Witnessed	0.36	0.25 to 0.53	<0.01	0.58	0.34 to 1.01	0.05	0.43	0.31 to 0.58	<0.01	0.60	0.42 to 0.85	0.01
Bystander CPR	1.96	1.41 to 2.72	<0.01	1.22	0.72 to 2.04	0.46	0.78	0.57 to 1.07	0.12
Shockable rhythm	0.51	0.37 to 0.71	<0.01	0.51	0.30 to 0.87	0.01	0.33	0.22 to 0.48	<0.01	0.62	0.39 to 0.99	0.05
Anoxic time^a	1.03	1.02 to 1.04	<0.01	1.05	1.03 to 1.06	<0.01	1.02	1.01 to 1.03	<0.01	1.02	1.01 to 1.03	<0.01
≥30 minutes	2.64	1.92 to 3.63	<0.01				1.83	1.37 to 2.45	<0.01
Cardiac cause	0.14	0.09 to 0.22	<0.01	0.19	0.11 to 0.35	<0.01	0.37	0.28 to 0.50	<0.01	0.55	0.38 to 0.79	<0.01
Variables after ROSC
STEMI	0.35	0.21 to 0.57	<0.01	0.78	0.38 to 1.60	0.49	0.66	0.39 to 1.12	0.12
Spontaneous breathing	0.19	0.14 to 0.27	<0.01	0.41	0.25 to 0.67	<0.01	0.27	0.20 to 0.38	<0.01	0.46	0.32 to 0.68	<0.01
Motor response	0.10	0.07 to 0.15	<0.01	0.23	0.13 to 0.41	<0.01	0.16	0.09 to 0.28	<0.01	0.45	0.24 to 0.85	0.01
Pupil light reflex	0.11	0.07 to 0.15	<0.01	0.26	0.16 to 0.42	<0.01	0.21	0.15 to 0.30	<0.01	0.43	0.30 to 0.64	<0.01
Hospital variable
TH volume	1.00	0.99 to 1.00	<0.01	1.00	1.00 to 1.01	0.21	1.00	0.99 to 1.00	<0.01	1.00	1.00 to 1.00	0.34
≥60	0.63	0.46 to 0.86	<0.01				0.77	0.58 to 1.03	0.08

CI, confidence interval; CPR, cardiopulmonary resuscitation; OR, odds ratio; ROSC, return of spontaneous circulation; STEMI, ST segment elevation myocardial infarction; TH, therapeutic hypothermia. ^aAnoxic time is the time from cardiac arrest to return of spontaneous circulation.

Back to article page

ISSN: 1364-8535

Contact us

Submission enquiries: journalsubmissions@springernature.com