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Table 5 Post-chemoprophylaxis intracranial hemorrhage expansion

From: Timing for deep vein thrombosis chemoprophylaxis in traumatic brain injury: an evidence-based review

Study Early ↑ ICH Agent CP day Number ICH ↑ Percentage
Arnold et al. [28] No E 8 99 2 2.0
Cothren et al. [21] No L 3 174 0 0.0
Depew et al. [22] No E ≤2 29 1 3.5
Depew et al. [22] No E >3 53 2 3.8
Dudley et al. [17] Yes L 3 287 1 0.3
Kim et al. [18] Yes H ≤3 47 0 0.0
Kleindienst et al. [23] No L 1 271 0 0.0
Koehler et al. [19] Yes L 3 268 4 1.5
Koehler et al. [19] Yes L 5 401 6 1.5
Kurtoglu et al. [20] Yes L 1 60 1 1.7
Levy et al. [11] Yes L 3 221 36 16.3
Levy et al. [11] No L 3 163 15 9.2
Minshall et al. [12] Yes L 2 158 8 5.1
Minshall et al. [12] Yes H 2 171 20 11.7
Norwood et al. [24] No L 1 36 0 0.0
Norwood et al. [24] No L 1 19 0 0.0
Norwood et al. [13] No L 1 150 6 4.0
Norwood et al. [14] No L 2 525 18 3.4
Pahatouridis et al. [25] No L 1 61 0 0.0
Phelan et al. [26] No L 1 34 2 5.9
Phelan et al. [26] No L 4 28 1 3.6
Saadeh et al. [15] Yes L 2 46 0 0.0
Saadeh et al. [15] Yes L ≥3 47 0 0.0
Salottolo et al. [27] No L <3 108 7 6.5
Salottolo et al. [27] No L ≥3 147 21 14.3
Scudday et al. [29] No E 4 402 11 2.7
Total     4,005 162 4.0
  1. Early ↑ ICH, included patients with pre-chemoprophylaxis intracranial hemorrhage (ICH) expansion; ↑ ICH, post-CP intracranial hemorrhage expansion; CP, chemoprophylaxis; E, either unfractionated heparin or low molecular weight heparin; H, unfractionated heparin; L, low molecular weight heparin.