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Table 4 Unadjusted and multivariable-adjusted odds ratios comparing ICU day 1 levels of hCAP18, 25D metabolites, and PTH and risk of 90-day mortality

From: Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients

Outcome

Unadjusted

Adjusted

 

Odds ratio (95% CI)

P value

Odds ratio (95% CI)

P value

hCAP18

    

 Tertile 1

4.80 (1.23-18.80)

0.02

4.49 (1.08-18.67)

0.04

 Tertile 2

2.69 (0.64-11.23)

0.18

3.00 (0.67-13.25)

0.15

 Tertile 3 (REF)

1.00

N/A

1.00

N/A

Total 25D

    

 Tertile 1

1.41 (0.47-4.24)

0.54

1.39 (0.41-4.73)

0.60

 Tertile 2

0.69 (0.21-2.40)

0.56

0.69 (0.19-2.56)

0.58

 Tertile 3 (REF)

1.00

N/A

1.00

N/A

Bioavailable 25D

    

 Tertile 1

0.97 (0.28-3.34)

0.96

1.11 (0.28-4.36)

0.88

 Tertile 2

1.17 (0.35-3.88)

0.80

1.39 (0.36-5.34)

0.63

 Tertile 3 (REF)

1.00

N/A

1.00

N/A

Free 25D

    

 Tertile 1

1.45 (0.41-5.06)

0.56

1.47 (0.37-5.82)

0.59

 Tertile 2

1.45 (0.41-5.06)

0.56

1.88 (0.44-8.05)

0.40

 Tertile 3 (REF)

1.00

N/A

1.00

N/A

PTH

    

 Tertile 1

1.00 (0.31-3.19)

>0.99

1.22 (0.36-4.13)

0.75

 Tertile 2

0.52 (0.14-1.95)

0.33

0.57 (0.15-2.25)

0.43

 Tertile 3 (REF)

1.00

N/A

1.00

N/A

  1. Twenty-one events. Adjusted models include age and APACHE II score. ICU, intensive care unit; hCAP18, human cathelicidin antimicrobial protein-18; 25D, 25-hydroxyvitamin D; PTH, parathyroid hormone; CI, confidence interval; APACHE II, acute physiology and chronic health evaluation II.