Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients

Table 2 hCAP18 and mineral metabolite/hormone levels on ICU days 1 and 3

Biomarker	Reference range	ICU day 1 (N = 121)	ICU day 3 (N = 111)^†	P value
hCAP18 (ng/ml)	Undefined	160 (106-286)	166 (116-291)	0.92
Total 25D (ng/ml)	30-80	17 (13-22)	17 (14-21)	0.42
Bioavailable 25D (ng/ml)	Undefined	2.5 (1.8-3.5)	2.4 (1.6-3.3)	0.24
Free 25D (pg/ml)	Undefined	9.6 (6.5-12.9)	9.5 (6.5-12.9)	0.98
DBP (mg/dl)	20-55	12.7 (9.4-17.1)	13.7 (10.1-17.1)	0.27
Albumin (g/dl)	4.1-5.3	3.1 (2.4-3.5)	2.9 (2.3-3.3)	0.002
PTH (pg/ml)	15-65	40 (28-56)	---	N/A

Values represent median (25^th to 75^th interquartile range). ^†Fewer samples were available on ICU day 3 due to interim death or discharge. ICU, intensive care unit; hCAP18, human cathelicidin antimicrobial protein-18; 25D, 25-hydroxyvitamin D; DBP, D-binding protein; PTH, parathyroid hormone.

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