From: The ratio of Th17/Treg cells as a risk indicator in early acute respiratory distress syndrome
Variables | Control | Acute respiratory distress syndrome | ¶ P -value | |||
---|---|---|---|---|---|---|
Total | Mild | Moderate | Severe | |||
Number | 26 | 79 | 24 | 28 | 27 | |
Age, years | 54.00 ± 13.77 | 55.03 ± 14.42 | 55.17 ± 15.45 | 53.36 ± 13.34 | 57.63 ± 15.57 | 0.714 |
Gender, male/female, n | 14/12 | 44/35 | 13/11 | 15/13 | 16/11 | 0.971 |
BMI, kg/m2 | 22.44 ± 3.53 | 24.03 ± 4.13 | 24.72 ± 4.98 | 24.67 ± 3.84 | 24.26 ± 3.93 | 0.150 |
Cause of ARDS | ||||||
Pneumonia | 25 | 6 | 9 | 10 | ||
Non-pulmonary sepsis | 19 | 4 | 8 | 7 | ||
Trauma | 23 | 9 | 6 | 8 | ||
Aspiration | 5 | 2 | 2 | 1 | ||
Multiple transfusions | 4 | 2 | 2 | |||
Others | 3 | 1 | 1 | 1 | ||
APACHE II score | 22 (20 to 26) | 20 (18 to 22) | 23 (21 to 26)* | 25 (22 to 27)* | <0.001 | |
SOFA score | 11.0 (10.0 to 13.0) | 9.5 (7.0 to 11.8) | 11.0 (10.0 to 13.0)* | 12.0 (11.0 to 13.0)* | <0.001 | |
Lung injury score | 2.3 (2.1 to 2.8) | 2.0 (1.9 to 2.1) | 2.3 (2.1 to 2.5)* | 2.9 (2.7 to 3.2)*# | <0.001 | |
PaO2/FiO2 (mmHg) | 138 (76 to 222) | 258 (223 to 273) | 139 (120 to 158)* | 67 (59 to 79)*# | <0.001 | |
CRP, mg/L | 4.97 (3.83 to 6.12) | 135.84 (116.83 to 156.79) | 116.69 (104.17 to 133.33) | 130.97 (123.40 to 154.45) | 156.85 (143.59 to 185.36)* | <0.001 |
PCT, ng/mL | 0.04 (0.02 to 0.06) | 1.56 (1.24 to 1.83) | 1.24 (1.05 to 136) | 1.47 (1.27 to 1.66) | 2.04 (1.62 to 2.61)*# | <0.001 |
Leukocytes, 109/L | 6.8 (5.6 to 8.2) | 12.9 (11.2 to 14.8) | 11.8 (10.5 to 12.8) | 12.4 (10.7 to 13.7) | 15.3 (13.6 to 17.6)*# | <0.001 |
Monocytes, 109/L | 0.58 (0.46 to 0.69) | 1.05 (0.92 to 1.23) | 0.95 (0.84 to 1.13) | 1.04 (0.88 to 1.23) | 1.12 (1.04 to 1.1.26)* | <0.001 |
Lymphocytes, 109/L | 3.09 (2.80 to 3.52) | 5.35 (4.25 to 6.47) | 4.24 (3.93 to 4.96) | 5.24 (4.19 to 6.06)* | 6.72 (5.69 to 7.45)*# | <0.001 |
Th17 cells, % of CD4+ | 0.71 (0.59 to 0.94) | 4.27 (3.67 to 6.02) | 3.54 (3.17 to 3.94) | 4.16 (3.96 to 4.54)* | 6.42 (5.96 to 6.91)*# | <0.001 |
Treg cells, % of CD4+ | 3.11 (2.70 to 3.44) | 5.37 (4.98 to 6.07) | 4.82 (4.50 to 5.18) | 5.46 (5.25 to 5.81)* | 6.18 (5.82 to 6.57)*# | <0.001 |
Th17/Treg ratio | 0.25 ± 0.09 | 0.86 ± 0.20 | 0.74 ± 0.12 | 0.77 ± 0.10 | 1.01 ± 0.18*# | <0.001 |
IL-6, pg/mL | 11.70 ± 1.31 | 758.33 ± 70.03 | 721.53 ± 54.43 | 763.62 ± 76.96* | 785.56 ± 62.36* | <0.001 |
IL-17, pg/mL | 20.27 ± 4.12 | 199.59 ± 68.12 | 139.42 ± 25.51 | 204.75 ± 37.64* | 247.72 ± 78.08*# | <0.001 |
IL-10, pg/mL | 123.04 ± 20.53 | 131.19 ± 19.94 | 137.8 ± 19.17 | 132.49 ± 20.14 | 124.17 ± 18.87 | 0.029 |
TGF-β1, pg/mL | 193.48 ± 46.48 | 209.92 ± 51.00 | 219.30 ± 61.84 | 200.30 ± 41.77 | 211.55 ± 49.25 | 0.264 |
28-day mortality, n, % | 32 (40.5%) | 7 (29.17%) | 12 (42.86%) | 13 (48.15%) |