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Table 2 Baseline characteristics of different subsets stratified by baseline APACHE II score

From: Benefit profile of recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis

  Moderate risk ( n= 86) High risk ( n= 41) Very high risk ( n= 35) P value a
Patient characteristics     
 Age (years) 67 (57 to 76) 69 (58 to 76) 72 (66 to 78) 0.171
 Male sex 50 (58%) 26 (63%) 17 (49%) 0.419
Illness severity     
 APACHE II score 19 (16 to 21) 27 (25 to 28) 33 (32 to 36) <0.001
 SOFA score 9 (7 to 11) 12 (11 to 13) 13 (11 to 15) <0.001
 Number of dysfunctional organs 3 (2 to 4) 4 (3 to 5) 5 (4 to 5) <0.001
 Positive blood culture 31 (36%) 23 (56%) 18 (51%) 0.067
 JAAM DIC score 6 (5 to 8) 6 (5 to 8) 8 (6 to 8) 0.092
 ISTH DIC score 4 (3 to 5) 4 (4 to 5) 5 (4 to 5) 0.018
Time from severe sepsis onset to study entry 0.035
 Early (≤48 hours) 53 (62%) 33 (81%) 28 (80%)  
 Late (>48 hours) 33 (38%) 8 (20%) 7 (20%)  
Infection site 0.457b
 Lung 17 (20%) 6 (15%) 9 (26%)  
 Abdomen 35 (41%) 16 (39%) 11 (31%)  
 Soft tissue 19 (22%) 9 (22%) 3 (9%)  
 Urinary tract 9 (11%) 5 (12%) 7 (20%)  
 Other/unknown 6 (7%) 5 (12%) 5 (14%)  
  1. APACHE, Acute Physiology and Chronic Health Evaluation; DIC, disseminated intravascular coagulation; ISTH, International Society on Thrombosis and Hemostasis; JAAM, Japanese Association for Acute Medicine; SOFA, Sequential Organ Failure Assessment. Data are expressed as group median (interquartile range) or proportions (%). a P value between three subsets in the Kruskal–Wallis or chi-square test. bOnly one P value, for site of infection, is shown because the test was performed as a chi-square test on a 3 × 5 crosstable.