Table 2 Baseline characteristics of different subsets stratified by baseline APACHE II score
Moderate risk ( n = 86) | High risk ( n = 41) | Very high risk ( n = 35) | P valuea | |
|---|---|---|---|---|
Patient characteristics | ||||
Age (years) | 67 (57 to 76) | 69 (58 to 76) | 72 (66 to 78) | 0.171 |
Male sex | 50 (58%) | 26 (63%) | 17 (49%) | 0.419 |
Illness severity | ||||
APACHE II score | 19 (16 to 21) | 27 (25 to 28) | 33 (32 to 36) | <0.001 |
SOFA score | 9 (7 to 11) | 12 (11 to 13) | 13 (11 to 15) | <0.001 |
Number of dysfunctional organs | 3 (2 to 4) | 4 (3 to 5) | 5 (4 to 5) | <0.001 |
Positive blood culture | 31 (36%) | 23 (56%) | 18 (51%) | 0.067 |
JAAM DIC score | 6 (5 to 8) | 6 (5 to 8) | 8 (6 to 8) | 0.092 |
ISTH DIC score | 4 (3 to 5) | 4 (4 to 5) | 5 (4 to 5) | 0.018 |
Time from severe sepsis onset to study entry | 0.035 | |||
Early (≤48 hours) | 53 (62%) | 33 (81%) | 28 (80%) | |
Late (>48 hours) | 33 (38%) | 8 (20%) | 7 (20%) | |
Infection site | 0.457b | |||
Lung | 17 (20%) | 6 (15%) | 9 (26%) | |
Abdomen | 35 (41%) | 16 (39%) | 11 (31%) | |
Soft tissue | 19 (22%) | 9 (22%) | 3 (9%) | |
Urinary tract | 9 (11%) | 5 (12%) | 7 (20%) | |
Other/unknown | 6 (7%) | 5 (12%) | 5 (14%) | |