Mean lactate-to-pyruvate ratio (LPR), glutamate, glucose, lactate, and pyruvate levels in the cerebral microdialysate and systemic glucose levels of 26 aneurysmal subarachnoid hemorrhage patients at given time points after neuromonitoring was started. Significant decrease of CMD-LPR (A), CMD-glutamate (B), and CMD-glucose (C). **P <0.01, ***P <0.001. Dashed lines indicate commonly used cutoffs (CMD-LPR at 40 and CMD-glucose at 0.7 mmol/L). Panel (D-F) Shows CMD-lactate, CMD-pyruvate and systemic glucose levels over time with significant increase of CMD-pyruvate levels (E) (*P <0.05). CMD-lactate (D) and systemic glucose levels (F) remained stable over the neuromonitoring time. Values are presented as mean ± standard error of the mean.