Skip to main content

Table 6 Studies reporting on ECCO 2 R for ARDS

From: Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review

  Gattinoni [ 67 ] Morris [ 14 ] Bein [ 11 ] Flörchinger [ 69 ] Brunet [ 87 ] Muellenbach [ 88 ] Nierhaus [ 89 ] Cho [ 90 ] Conrad [ 91 ] Iglesias [ 68 ]
Country Italy USA Germany Germany France Germany Germany Korea USA Spain
Design Case series RCT RCT Case series Case series Case series Case series Case series Case series Case series
Prospective Y Y Y Y Y N N Y Y Y
Setting Single Mulit Multi Single Single Single Single Single Multi Single
Quality assessment§ RCT5 RCT6
Type of CO2 removal device, AV/VV VV VV AV AV VV AV AV AV AV AV
Patients received ECCO2R, n 43 21 40 159 23 22 13 11 8 7
Years 1980–1985 1987–1991 2007–2010 1996–2007 1989–1991 2002–2006 2010 1997–1999 2005–2006
Age, years    50 ± 12 44 ± 17 29 ± 10 38 ± 15 52 ± 19 58 ± 15 44 ± 8 53.7 ± 16.0
SOFA score    159 15 ± 5 8.8 ± 1.8
Pre-CO2 removal           
PO2/FiO2, mmHg 67   152 ± 37 72 ± 37 84 ± 30 61 (47–85)$ 100 ± 29 110 ± 36.6 90
PCo2, mmHg 49 ± 11   57 ± 12 65 ± 24 56 ± 20 65 (54–72)$ 80 ± 23 84 ± 23 90.8 ± 7.5 70
Plateau pressure, cmH2O   29 ± 5 37 ± 6* 51 ± 9* 40 (36–46)*$ 34 ± 3* 30.1 ± 7.1 22.0 ± 7.4
Lung injury score   2.8 ± 0.7 3.4 ± 0.4 3.5 (3–3.7) 2.9 ± 0.3
Delay MV – extracorporeal CO2 removal, days   <7 7 ± 13 9.2 ± 7.7 1 (0.5–1.9) 9.4 ± 10.2 8.6 ± 12.6 4 ± 2
Post-cannulation PCo2 (24 h), mmHg   35 ± 7 41 ± 7 39 (36–42)$ 54 ± 19 40.7 ± 10.2 51.8 ± 3.1 45
Length of CO2 removal device, days 8 ± 5   7.4 ± 4.0 8 ± 6 13 (1–55) 5.3 (3.2–8.2) 12 ± 22 8.6 ± 9.4 4.3 ± 2.5
Serious complication, n (%) 3 (7)   3 (7) 25 (16) 5 (22) 5 (23) 2 (15) 3 (27) 0 (0) 1 (14
Ischemia lower limb   1 (2) 13 (8) 3 (14) 0 0 0 0
Compartmental syndrome   4 (2.5) 1 (4) 0 0 0 0
Cannula thrombosis   8 (5) 0 0 0 1
Mortality, n (%) 22 (51) 7 (33) 7 (17) 104 (65) 12 (52) 6 (27) 7 (54) 9 (82) 4 (50) 1 (14)
  1. AV: arteriovenous; VV: veno-venous; Multi: multicenter; MV: mechanical ventilation; N: no; RCT: randomized controlled trial; SOFA: Sequential Organ Failure Assessment; Y: yes; *Peak pressure; §RCT quality was graded using a nine-point scale combining elements from Jadad’s [21] and Chalmers’ scales [23,24] whereas the validity of case-controlled studies was appraised with the Newcastle-Ottawa scale [25]. Data are given as mean ± SD or median (interquartile range).