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Table 5 Studies of ECMO for H1N1-associated ARDS reporting on ≤ 10 patients

From: Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review

  Roncon [ 42 ] D’Ancona [ 38 ] Roch [ 41 ] Hou [ 45 ] Bonastre [ 47 ] Turner [ 44 ] Chan [ 37 ] Freed [ 39 ]
Country Portugal Italy France China Spain USA Hong Kong Canada
Patients, n 10 10 9 9 9 7 7 6
Study design Case series Case series Case series Case series Case series Case series Case series Case series
Number of centers 1 1 1 1 5 1 3 4
Age, years 40 (36–47) 36 (23–55) 49 (26–57) 31 ± 11 36 (28–42) 24 (16–25) 42 (39–50) 33 ± 7
BMI, kg/m2 26 (21–48) 30 (25–80) 27 (26–29) 26 (26–27) 33 ± 7
Pregnant or postpartum 1(10) 0 (0) 1 (11) 4 (44) 1 (14) 0 (0)
SOFA 9 (8–10)
Interval MV-ECMO, d 6.5 (2.2–12.2) 0.5 (0.25–4.0) 6 (2–10) 5 (2–7) 6.0 (1.5–12.5) 5.0 (2.5–8.3)
Pre-ECMO parameter         
pH 7.33 (7.28–7.38) 7.17 (7.04–7.25)   7.30 (7.19–7.36) 7.31 ± 0.05
PaO2/FiO2, mmHg 69 (56–84) 52 (50–60) 53 (45–64) 66 (64–102) 57 (51–62) 56 (53–71) 58 ± 17
Plateau pressure, mmHg 35 (32–36) 31 (30–35) 33 (30–35)* 44 ± 42*
Lung injury score 3.5 (3.3–3.8) 3.6 (3.3–3.7) 3.6 (3.25–3.75) 3.8 (3.8–3.9)
Any rescue therapy, % 70 100 100 14 100
Nitric oxide, % 60 67   100 0 67
Prone position, % 10 22   0 14 33
Duration of ECMO, days 22 (14–32) 9 (4–14) 18 (3–90) 6 (5–22) 13 (8–37) 6 (6–10) 15 (14–15)
Mortality, n (%) 4 (40) 5 (50) 5 (56) 4 (44) 5 (56) 2 (28) 1 (14) 2 (33)
  1. BMI: Body mass index; SOFA: Sequential Organ Failure Assessment; MV: mechanical ventilation;
  2. Data are given as mean ± SD or median (interquartile range). *Peak pressure.