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Table 4 Frequency distribution of rs653765 and rs514049 genotypes and alleles between sepsis subtypes

From: An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis

  Sepsis subtype Severe sepsis Septic shock Severe sepsis/septic shock P 1 P 2 P 3 P 1* P 2* P 3*
(n = 55) (%) (n = 288) (%) (n = 97) (%) (n = 385) (%)
rs653765 C > T          
CC 35 (63.6) 238 (82.6) 73 (75.3) 311 (80.8) 0.0014 0.129 0.0037 0.0014 0.129 0.0037
CT/TT 20 (36.4) 50 (17.4) 24 (24.7) 74 (19.2) - - - - - -
C 87 (79.1) 520 (90.3) 167 (86.1) 687 (89.2) 0.0008 0.114 0.0023 0.0014 0.129 0.0037
T 23 (20.9) 56 (9.7) 27 (13.9) 83 (10.8) - - - - - -
rs514049 A > C          
AA 45 (81.8) 252 (87.5) 91 (93.8) 343 (89.1) 0.257 0.021 0.118 0.428 0.024 0.210
AC/CC 10 (18.2) 36 (12.5) 6 (6.2) 42 (10.9) - - - - - -
A 100 (90.9) 536 (93.1) 188 (96.9) 724 (94.0) 0.428 0.024 0.210 0.428 0.024 0.210
C 10 (9.1) 40 (6.9) 6 (3.1) 46 (6.0) - - - - - -
  1. P1, sepsis group versus severe sepsis; P2, sepsis group versus septic shock; P3, sepsis group versus severe sepsis/septic shock. *False discovery rate-adjusted P-value for multiple hypotheses testing using the Benjamin-Hochberg method.