An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis

Table 4 Frequency distribution of rs653765 and rs514049 genotypes and alleles between sepsis subtypes

	Sepsis subtype	Severe sepsis	Septic shock	Severe sepsis/septic shock	P 1	P 2	P 3	P 1*	P 2*	P 3*
	(n = 55) (%)	(n = 288) (%)	(n = 97) (%)	(n = 385) (%)	P 1	P 2	P 3	P 1*	P 2*	P 3*
rs653765 C > T
CC	35 (63.6)	238 (82.6)	73 (75.3)	311 (80.8)	0.0014	0.129	0.0037	0.0014	0.129	0.0037
CT/TT	20 (36.4)	50 (17.4)	24 (24.7)	74 (19.2)	-	-	-	-	-	-
C	87 (79.1)	520 (90.3)	167 (86.1)	687 (89.2)	0.0008	0.114	0.0023	0.0014	0.129	0.0037
T	23 (20.9)	56 (9.7)	27 (13.9)	83 (10.8)	-	-	-	-	-	-
rs514049 A > C
AA	45 (81.8)	252 (87.5)	91 (93.8)	343 (89.1)	0.257	0.021	0.118	0.428	0.024	0.210
AC/CC	10 (18.2)	36 (12.5)	6 (6.2)	42 (10.9)	-	-	-	-	-	-
A	100 (90.9)	536 (93.1)	188 (96.9)	724 (94.0)	0.428	0.024	0.210	0.428	0.024	0.210
C	10 (9.1)	40 (6.9)	6 (3.1)	46 (6.0)	-	-	-	-	-	-

P1, sepsis group versus severe sepsis; P2, sepsis group versus septic shock; P3, sepsis group versus severe sepsis/septic shock. *False discovery rate-adjusted P-value for multiple hypotheses testing using the Benjamin-Hochberg method.

ISSN: 1364-8535