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Table 3 Frequency distribution of rs653765 and rs514049 genotypes and alleles in sepsis patients and healthy controls

From: An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis

 

Cases (n = 440) (%)

Controls (n = 450) (%)

P

P *

Adjusted odds ratio (95% CI)

rs653765 C > T

     

CC

346 (78.6)

338 (75.1)

0.234

0.234

-

CT

82 (18.6)

91 (20.2)

-

-

-

TT

12 (2.7)

21 (4.7)

-

-

-

CC/CT

428 (97.3)

429 (95.3)

0.126

0.234

1.746 (0.848, 3.594)

TT/CT

94 (21.4)

112 (24.9)

0.213

0.234

0.820 (0.600, 1.121)

C

774 (88.0)

767 (85.2)

-

-

1.000 (reference)

T

106 (12.0)

133 (14.8)

0.091

0.234

0.790 (0.600, 1.039)

rs514049 A > C

     

AA

388 (88.2)

394 (87.6)

0.954

1.000

-

AC

48 (10.9)

52 (11.6)

-

-

-

CC

4 (0.9)

4 (0.9)

-

-

-

AA/AC

436 (99.1)

446 (99.1)

1.000

1.000

0.978 (0.243, 3.935)

AC/CC

52 (11.8)

56 (12.4)

0.775

1.000

0.943 (0.630, 1.411)

A

824 (93.6)

840 (93.3)

  

1.000 (reference)

C

56 (6.4)

60 (6.7)

0.796

1.000

0.952 (0.653, 1.387)

  1. *False discovery rate-adjusted P-value for multiple hypotheses testing using the Benjamin-Hochberg method.