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Table 3 Frequency distribution of rs653765 and rs514049 genotypes and alleles in sepsis patients and healthy controls

From: An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis

  Cases (n = 440) (%) Controls (n = 450) (%) P P * Adjusted odds ratio (95% CI)
rs653765 C > T      
CC 346 (78.6) 338 (75.1) 0.234 0.234 -
CT 82 (18.6) 91 (20.2) - - -
TT 12 (2.7) 21 (4.7) - - -
CC/CT 428 (97.3) 429 (95.3) 0.126 0.234 1.746 (0.848, 3.594)
TT/CT 94 (21.4) 112 (24.9) 0.213 0.234 0.820 (0.600, 1.121)
C 774 (88.0) 767 (85.2) - - 1.000 (reference)
T 106 (12.0) 133 (14.8) 0.091 0.234 0.790 (0.600, 1.039)
rs514049 A > C      
AA 388 (88.2) 394 (87.6) 0.954 1.000 -
AC 48 (10.9) 52 (11.6) - - -
CC 4 (0.9) 4 (0.9) - - -
AA/AC 436 (99.1) 446 (99.1) 1.000 1.000 0.978 (0.243, 3.935)
AC/CC 52 (11.8) 56 (12.4) 0.775 1.000 0.943 (0.630, 1.411)
A 824 (93.6) 840 (93.3)    1.000 (reference)
C 56 (6.4) 60 (6.7) 0.796 1.000 0.952 (0.653, 1.387)
  1. *False discovery rate-adjusted P-value for multiple hypotheses testing using the Benjamin-Hochberg method.