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Figure 1 | Critical Care

Figure 1

From: An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis

Figure 1

Expression levels of A disintegrin and metalloproteinase 10 (ADAM10) polymorphisms in sepsis patients and healthy controls. Expression levels of ADAM10 in sepsis patients and healthy controls (A). Expression levels of ADAM10 in sepsis, severe sepsis and septic shock subgroup (B); the genotype distribution between the rs653765 polymorphisms and the expression of the ADAM10 gene (C); the genotype distribution between the rs514049 polymorphisms and the expression of the ADAM10 gene in severe sepsis (D); effect of rs514049-rs653765 haplotypes on transcriptional activity of ADAM10. In luciferase assays in THP-1 cells, luciferase activity was presented as a ratio (Firefly/Renilla) (E); the horizontal line represents the mean expression level of ADAM10 with each group. *P <0.05; **P <0.01; ***P <0.001.

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Critical Care

ISSN: 1364-8535