Incidence and outcome of inappropriate in-hospital empiric antibiotics for severe infection: a systematic review and meta-analysis

Table 3 Summary of mortality data included in the meta-analysis

Reference	Time of mortality assessment	AAT mortality rate, %	IAAT mortality rate, %	P value
Kim et al. [21]	30	36.67	41.24	0.36
Kang et al. [12]	30	27.41	38.41	0.049
Micek et al. [33]	IHM	17.83	30.67	0.018
Scarsi et al. [22]	IHM	16.07	13.60	0.48
Marschall et al. [36]	IHM	14.03	13.92	1.0
Shorr et al. [37]	IHM	11.94	19.64	0.15
Rodríguez-Baño et al. [38]	30	18.18	24.24	0.3
Ammerlaan et al. [39]	30	25.00	21.27	NS
Erbay et al. [19]	30	39.53	65.00	0.011
Kumar et al. [40]	IHM	48.00	89.70	<0.0001
Tseng et al. [41]	IHM	35.44	50.00	OR 2.17 (1.4-3.38) 0.001
Micek et al. [42]	IHM	36.40	51.68	<0.001
Paul et al. [43]	30	33.33	49.12	0.001
Joung et al. [44]	30	22.45	49.25	<0.0001
Suppli et al. [46]	30	20.55	40.00	0.009
Reisfeld et al. [47]	30	33.48	46.36	OR 1.4 (0.86-2.29) (NS)
Wilke et al. [48]	IHM	14.02	26.32	0.021
Lye et al. [50]	IHM	19.16	26.19	OR 0.67 (0.46-0.96) 0.03
Labelle et al. [54]	IHM	51.38	68.30	<0.001
Frakking et al. [56]	30	18.82	20.41	NS
Tumbarello et al. [57]	IHM	24.07	64.29	<0.001

AAT, appropriate antibiotic therapy; IAAT, inappropriate antibiotic therapy; IHM, in-hospital mortality; OR, odds ratio; NS, not significant.

ISSN: 1364-8535