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Table 1 Characteristics of 27 included studies in the systematic review

From: Incidence and outcome of inappropriate in-hospital empiric antibiotics for severe infection: a systematic review and meta-analysis

Reference

Study year(s)

Location

Design

Center

Number of patients

Outcome

Main type of infection

Severity index scale and significance difference

Number

Type

Kim et al. [21]a

1998-2001

Korea

R

1

U

127

M

MRSA bacteremia

McCabe’s classification, Jackson: NS

Kang et al. [12]a

1998-2002

Korea

R

2

U, G

286

M

Antibiotic-resistant Gram-negative Bacilli BSI

APACHE II: NS

Micek et al. [33]a

1997-2002

USA

R

1

U

305

M

Pseudomonas aeruginosa BSI

SAPS II: NC

Luna et al. [34]

1999-2003

Argentina

P

6

NM

76

M

Pneumonia (VAP)

APACHE II: NS

Kim et al. [8]

1998-2001

South Korea

R

1

U

238

M

SAB

McCabe’s classification, Jackson: NS

Scarsi et al. [22]a

2001-2003

USA

R

1

U

884

M

Gram-negative BSI

Charlson index: NS

Marschall et al. [36]a

2006-2007

USA

P

1

T

250

M LOS

Gram-negative bacteremia

Charlson index, McCabe’s classification: NS

Shorr et al. [37]a

2002-2004

USA

R

1

U

291

M LOS C

MRSA infection

NM

Rodríguez-Baño et al. [38]a

2003

Spain

P

59

U, G

209

M

Sepsis

Charlson index: NC

Ammerlaan et al. [39]a

2007

West European countries

R

60

T, G

334

M

SAB

Modified Charlson index: NS

Erbay et al. [19]a

2005-2008

Turkey

R

1

U

103

M

Acinetobacter baumannii bacteremia

APACHE II: NC

Kumar et al. [40]a

1996-2005

Canada, USA, Saudi Arabia

R

22

U

5,715

M

Septic shock

APACHE II: NC

Tseng et al. [41]a

2005-2007

Taiwan

R

1

T

163

M

Pneumonia

Charlson index: NC

Micek et al. [42]a

2002-2007

USA

R

1

U

760

M

Gram-negative sepsis

APACHE II, Charlson index: NS

Paul et al. [43]a

1999-2007

Israel

R

1

NM

510

M

MRSA bacteremia

NM

Joung et al. [44]a

2000-2006

Korea

R

1

U

116

M

Pneumonia (HAP) Acinetobacter baumannii

APACHE II: NS

Shorr et al. [45]

2002-2007

USA

R

1

U

760

LOS

Gram-negative sepsis

APACHE II, Charlson index: NS

Suppli et al. [46]a

2002-2005

Denmark

R

1

T

196

M

Enterococcal BSI

Charlson index: NS, except score 0 (P = 0.04)

Reisfeld et al. [47]a

2005-2007

Israel

R

1

G

378

M

Gram-negative bacteremia

NM

Wilke et al. [48]a

2007

Germany

R

5

T

221

M LOS C

Pneumonia (VAP, HAP)

NM

Lye et al. [50]a

2007-2009

Singapore

R

2

G

675

M

Gram-negative bacteremia

APACHE II <0.001; Charlson index: NS

Tseng et al. [51]

2007-2008

Taiwan

R

1

U

163

M

Pneumonia (VAP)

APACHE II, Charlson index, SOFA: NC

Chen et al. [52]

2006-2011

China

R

1

T

118

M

SAB

APACHE II: NC

Labelle et al. [54]a

2002-2007

USA

R

1

T

436

M

Septic shock

APACHE II, Charlson index: NC

Chen et al. [55]

2008-2009

Taiwan

P

1

U

937

M, LOS

BSI

MEDS, Charlson index: NC

Frakking et al. [56]a

2008-2010

The Netherlands

R

8

U

232

M

ESBL bacteremia

Pitt bacteremia score: NS

Tumbarello et al. [57]a

2008-2010

Italy

R

1

U

110

M

Pseudomonas aeruginosa pneumonia

SAPS II, SOFA: NS

  1. aTwenty-one included studies in meta-analysis. APACHE II, Acute Physiology and Chronic Health Evaluation II; BSI, bloodstream infection; C, costs; ESBL, extended-spectrum β-lactamase; G, general hospital; HAP, hospital-acquired pneumonia; LOS: Length Of Stay; M, mortality; MEDS, Mortality in Emergency Department Sepsis; MRSA, Methicillin-resistant Staphylococcus Aureus; NC, no comparison; NM, not mentioned; NS, not significant; P, prospective; R, retrospective; SAB, Staphylococcus Aureus bacteraemia; SAPS II, Simplified Acute Physiology Score II; SOFA, Sequential Organ Failure Assessment; T, teaching hospital, U, university hospital; USA, United States of America; VAP, ventilator-associated pneumonia.