Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature

Table 2 Observational studies assessing the effect of mean arterial pressure on outcomes

Reference	Type of study	Number of patients	Primary outcomes	MAP, mm Hg	Severity score	28-day mortality, %
Varpula et al. [1] (2005)	Retrospective cohort	111	30-day mortality	65	APACHE II: 17	33.3
Dünser et al. [2] (2009)	Retrospective cohort	274	28-day mortality	>60	SAPS: 52 APACHE II: 27	27.7
Dünser et al. [25] (2009)	Post hoc analysis	290	28-day mortality	>70	SAPS II: 58	76
Badin et al. [26] (2011)	Prospective cohort	217	Acute kidney injury at 72 hours	72-82	SAPS II: 53	39^a
Poukkanen et al. [27] (2013)	Prospective cohort	423	Acute kidney injury at day 5	73	SAPS II: 40	24^a

^aHospital mortality was reported instead of 28-day mortality. APACHE II, Acute Physiology and Chronic Health Evaluation II; MAP, mean arterial pressure; NA, not available; SAPS II, Simplified Acute Physiology Score II.

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