Table 1 Studies comparing different levels of mean arterial pressure in septic shock
From: Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature
Reference | Study design | Number of patients | Targeted MAP, mm Hg | Primary outcomes | Severity score | 28-day mortality, % |
|---|---|---|---|---|---|---|
LeDoux et al. [18] (2000) | Prospective cohort | 10 | 65, 75, 85 | Regional circulation and oxygen metabolism | APACHE II: 29 | 70 |
Bourgoin et al. [19] (2005) | Randomized clinical trial | 28 | 65, 85 | Regional circulation and oxygen metabolism | APACHE II: 27 | NA |
Deruddre et al. [20] (2007) | Prospective cohort | 11 | 65, 75, 85 | Renal perfusion | SAPS II: 57 | NA |
Jhanji et al. [21] (2009) | Prospective cohort | 16 | 60, 70, 80, 90 | Microcirculation | APACHE II: 23 | 62.5 |
Thooft et al. [22] (2011) | Prospective cohort | 13 | 65, 75, 85, 65 | Microcirculation | APACHE II: 23 | 17 |
Dubin et al. [23] (2009) | Prospective cohort | 20 | 65, 75, 85 | Microcirculation | APACHE II: 24 | 50 |
Asfar et al. [24] (2014) | Randomized clinical trial | 776 | 65, 85 | 28-day mortality | SAPS II: 57 | 35 |