Dynamic changes of microbial flora and therapeutic consequences in persistent peritonitis

Table 8 Univariate and multivariate analyses of risk factors for emergence of MDR microorganisms among the 173 reoperations in 98 patients with persistent peritonitis

Variable	Univariate analysis						Multivariate analysis
Variable	Missing data	Emerging MDR strains (n = 63)	No emergence of MDR strains (n = 110)	Odds ratio	95% CI	P -value	Odds ratio	95% CI	P -value
Type 1 diabetes mellitus	0	10 (16)	7 (6)	2.77	0.99, 7.08	0.061	-	-	-
SOFA score, per one point	0	8 ± 4	7 ± 3	1.07	0.97, 1.17	0.17	-	-	-
Time to reoperation, days	0	7 ± 6	4 ± 3	1.19	1.08, 1.32	<0.0001	1.19	1.08-1.33	0.0006
Polymicrobial initial infection	0	39 (62)	86 (78)	0.453	0.23, 0.89	0.034	-	-	-
Duration of anti-infective therapy, days	0	8 ± 5	6 ± 4	1.12	1.04, 1.21	0.0003	-	-	-
Use of third-generation cephalosporins	0	3 (5)	13 (12)	0.37	0.10, 1.36	0.17	-	-	-
Use of fluoroquinolones	0	9 (14)	5 (5)	3.5	1.12, 10.95	0.039	-	-	-

Results are expressed as mean ± SD or total number (%). An interaction between time to reoperation and duration of antibiotic therapy was identified (Pearson correlation coefficient between the two variables = 0.46 (95% CI 0.33, 0.57) (P <0.0001)). An interaction term was added in the multivariate analyses of risk factors for emergence of MDR microorganisms, which did not modify the results. C-index: 0.69 (95% CI: 0.61, 0.77); Hosmer-Lemeshow test P-value: 0.08. MDR, multidrug-resistant.

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