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Table 8 Univariate and multivariate analyses of risk factors for emergence of MDR microorganisms among the 173 reoperations in 98 patients with persistent peritonitis

From: Dynamic changes of microbial flora and therapeutic consequences in persistent peritonitis

Variable Univariate analysis Multivariate analysis
Missing data Emerging MDR strains (n = 63) No emergence of MDR strains (n = 110) Odds ratio 95% CI P -value Odds ratio 95% CI P -value
Type 1 diabetes mellitus 0 10 (16) 7 (6) 2.77 0.99, 7.08 0.061 - - -
SOFA score, per one point 0 8 ± 4 7 ± 3 1.07 0.97, 1.17 0.17 - - -
Time to reoperation, days 0 7 ± 6 4 ± 3 1.19 1.08, 1.32 <0.0001 1.19 1.08-1.33 0.0006
Polymicrobial initial infection 0 39 (62) 86 (78) 0.453 0.23, 0.89 0.034 - - -
Duration of anti-infective therapy, days 0 8 ± 5 6 ± 4 1.12 1.04, 1.21 0.0003 - - -
Use of third-generation cephalosporins 0 3 (5) 13 (12) 0.37 0.10, 1.36 0.17 - - -
Use of fluoroquinolones 0 9 (14) 5 (5) 3.5 1.12, 10.95 0.039 - - -
  1. Results are expressed as mean ± SD or total number (%). An interaction between time to reoperation and duration of antibiotic therapy was identified (Pearson correlation coefficient between the two variables = 0.46 (95% CI 0.33, 0.57) (P <0.0001)). An interaction term was added in the multivariate analyses of risk factors for emergence of MDR microorganisms, which did not modify the results. C-index: 0.69 (95% CI: 0.61, 0.77); Hosmer-Lemeshow test P-value: 0.08. MDR, multidrug-resistant.