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Table 3 Multivariate analysis examining the association between age and complicated outcome and mortality after severe blunt trauma

From: Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock

Risk factor

Odds ratio (95% CI)

P -value

Complicated outcome1

New injury severity score >34

2.82 (2.26 to 3.51)

<0.001

Total blood >9.5 U, 0 to 12 hours

2.72 (2.06 to 3.59)

<0.001

Age ≥55, years

2.25 (1.76 to 2.89)

<0.001

Lactate >6, mmol/L, 0 to 6 hours

1.82 (1.41 to 2.36)

<0.001

Body mass index >28, kg/m2

1.56 (1.26 to 1.94)

<0.001

ED SBP <90, mmHg

1.46 (1.16 to 1.85)

<0.001

Crystalloid >12.5, L, 0 to 12 hours

1.43 (1.12 to 1.83)

0.004

Major medical comorbidity, ≥1

1.34 (1.05 to 1.72)

0.019

Mortality at 28 days2

Total Blood > 9.5 (U) 0 to 12 hours

3.91 (2.93 to 5.22)

<0.001

Lactate >6, mmol/L, 0 to 6 hours

2.22 (1.67 to 2.96)

<0.001

Age ≥55, years

2.12 (1.59 to 2.82)

<0.001

New injury severity score >34

1.74 (1.32 to 2.29)

<0.001

ED SBP <90, mmHg

1.66 (1.20 to 2.30)

0.002

  1. 1Model fit statistics: area under the curve (AUC), c = 0.748; Akaike information criterion (AIC) = 1982; likelihood ratio test, P <0.0001). 2Model fit statistics: AUC, c = 0.775; AIC = 1433; likelihood ratio test, P <0.0001). All risk factors were found to be significant, defined as a P-value <0.05. Complicated outcome is defined as >14 days of persistent organ dysfunction or death. U, units; ED, emergency department; SBP, systolic blood pressure.