Skip to main content

Table 3 Multivariate analysis examining the association between age and complicated outcome and mortality after severe blunt trauma

From: Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock

Risk factor Odds ratio (95% CI) P -value
Complicated outcome1
New injury severity score >34 2.82 (2.26 to 3.51) <0.001
Total blood >9.5 U, 0 to 12 hours 2.72 (2.06 to 3.59) <0.001
Age ≥55, years 2.25 (1.76 to 2.89) <0.001
Lactate >6, mmol/L, 0 to 6 hours 1.82 (1.41 to 2.36) <0.001
Body mass index >28, kg/m2 1.56 (1.26 to 1.94) <0.001
ED SBP <90, mmHg 1.46 (1.16 to 1.85) <0.001
Crystalloid >12.5, L, 0 to 12 hours 1.43 (1.12 to 1.83) 0.004
Major medical comorbidity, ≥1 1.34 (1.05 to 1.72) 0.019
Mortality at 28 days2
Total Blood > 9.5 (U) 0 to 12 hours 3.91 (2.93 to 5.22) <0.001
Lactate >6, mmol/L, 0 to 6 hours 2.22 (1.67 to 2.96) <0.001
Age ≥55, years 2.12 (1.59 to 2.82) <0.001
New injury severity score >34 1.74 (1.32 to 2.29) <0.001
ED SBP <90, mmHg 1.66 (1.20 to 2.30) 0.002
  1. 1Model fit statistics: area under the curve (AUC), c = 0.748; Akaike information criterion (AIC) = 1982; likelihood ratio test, P <0.0001). 2Model fit statistics: AUC, c = 0.775; AIC = 1433; likelihood ratio test, P <0.0001). All risk factors were found to be significant, defined as a P-value <0.05. Complicated outcome is defined as >14 days of persistent organ dysfunction or death. U, units; ED, emergency department; SBP, systolic blood pressure.