Plasma cytokine and chemokine levels in complicated aged and young patients at 12, 24, 96, 185, 336, 504 and 672 hours after severe injury and hemorrhage. The elderly had significantly less cytokine and chemokine concentrations in their plasma after severe blunt trauma. General linear model analysis was performed to examine the significance in relationship of age and time after injury, to the differences seen in the concentrations cytokines and chemokines between the cohorts. Analysis of the plasma demonstrated that both age and time had significant effects on the differences observed for the levels of IL-6, IL-8, IL-10 and MCP-1 (*model P <0.05). Model analysis of IL-1β and TNF-α found that only age had a significant effect on the differences observed (҂
P <0.05). Neither age, nor time after traumatic injury, were found to have significant effect on the levels of IP-10 (data not shown).