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Figure 3 | Critical Care

Figure 3

From: Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock

Figure 3

Selected gene ontology pathway heat maps in complicated aged and young patients on days 0.5, 1.0 and 4.0 after severe traumatic injury. Dark blue represents upregulation, whereas light blue represents down regulation. In complicated young patients, gene ontology pathway analysis demonstrated that several pathways involved in innate immunity and neutrophil function (that is, antigen processing and presentation and neutrophil chemotaxis pathways) were significantly more aberrant from controls in the acute periods (days 0.5 and 1) than was seen in the aged. In the sub-acute period (day 4) after injury, these patterns switched. The young trended back toward baseline expression values while the aged continued to demonstrate significantly more aberrant expression patterns in pathways involved in innate immunity and neutrophil function (that is, neutrophil activation pathway) (Holm-Sidak, * P <0.05).

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Critical Care

ISSN: 1364-8535