Sensitivity analysis of the pooled data: dexmedetomidine versus standard care sedatives | Difference in mean costs, € | Difference in median costs, € |
---|---|---|
S1. Standard sedative cost set to zero | −1,545 | −2,515 |
S2. Dexmedetomidine cost increased to €22 per 200 μg (€0.11 per 1 μg) | −1,580 | −2,591 |
S3. Cost of a NIV day (24 hours) decreased to €1,390 | −1,779 | −2,717 |
S4. Cost of a NIV day (24 hours) increased to €1,850 | −1,614 | −2,551 |
S5. Patients with observed data from all three time periods (no censoring, no imputation). N (dexmedetomidine): 366; N (standard care): 391 | −3,213 | −2,462 |
S6. Patients of those 18 study centers, from which the ICU unit costs were obtained. N (dexmedetomidine): 170; N (standard care): 166 | −1,763 | −4,567 |
S7a. TISS-based total ICU costs, at unit cost of €40 per TISS point | −1,499 | −1,448 |
S7b. TISS-based total ICU costs, at unit cost of €50 per TISS point | −1,926 | −1,782 |
S8a. Only declining direct variable daily costs included, assuming they represent 25% of total ICU costs | −256 | −515 |
S8b. Only declining direct variable daily costs included, assuming they represent 50% of total ICU costs | −720 | −1,343 |