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Table 1 Resource utilization

From: Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation

1a.

Time to extubation, hours

P value

Mean (SD)

Median (IQR)

Dexmedetomidine

Standard care

Dexmedetomidine

Standard care

Pooled

166.1 (219.5)

195.1 (220.6)

89.0 (46.0-188.0)

118.0 (53.0-231.0)

0.0003

MIDEX

183.8 (226.4)

214.9 (229.3)

95.0 (59.0-212.0)

143.0 (75.0-232.0)

0.0013

PRODEX

148.3 (211.3)

175.1 (210.0)

69.0 (39.0-164.0)

91.0 (44.0-231.0)

0.0405

1b.

Duration of mechanical ventilation, hours

P value

Mean (SD)

Median (IQR)

Dexmedetomidine

Standard care

Dexmedetomidine

Standard care

Pooled

192.7 (241.1)

213.2 (229.1)

103.0 (51.0-215.0)

139.0 (70.0-265.0)

0.0052

MIDEX

199.2 (237.5)

231.4 (239.9)

115.0 (66.0-216.0)

146.5 (84.0-260.0)

0.0047

PRODEX

186.3 (245.0)

194.7 (216.7)

94.0 (45.0-211.0)

114.0 (47.0-266.0)

0.2049

1c.

Duration of actual ICU stay, hours

P value

Mean (SD)

Median (IQR)

Dexmedetomidine

Standard care

Dexmedetomidine

Standard care

Pooled

271.3 (267.2)

296.0 (265.6)

166.5 (98.5-315.0)

196.0 (116.0-361.0)

0.0210

MIDEX

281.8 (265.0)

318.4 (265.8)

179.5 (115.0-341.0)

217.0 (126.0-365.0)

0.0131

PRODEX

260.8 (269.6)

273.3 (265.0)

146.0 (94.0-293.0)

169.0 (93.0-355.0)

0.4057

1d.

Cumulative sum of TISS points

P value

Mean (SD)

Median (IQR)

Dexmedetomidine

Standard care

Dexmedetomidine

Standard care

Pooled

360 (375)

403 (360)

239 (152-426)

279 (177-503)

0.0030

MIDEX

353 (328)

419 (372)

239 (157-428)

300 (181-507)

0.0094

PRODEX

368 (419)

386 (347)

242 (139-421)

273 (170-501)

0.1064

  1. Duration of ventilator use (1a-b), intensive care unit (ICU) stay (1c), and cumulative sum of Therapeutic Intervention Scoring System (TISS) points (1d) are derived from MIDEX and PRODEX for the economic analysis. In MIDEX, the standard care sedative was midazolam; in PRODEX, it was propofol. IQR, interquartile range (first to third); SD, standard deviation.