Impact of the underlying mean intensive care unit (ICU) daily cost level on the total ICU cost difference between dexmedetomidine (D) and standard care (SC). The three ICU period-specific daily costs were varied up or down from the base case values that reflected an overall mean cost of €1,702 per ICU day (triangle). Alternative period-specific unit costs reflecting a mean cost range between €500 and €3,100 per ICU day were tested. Negative values indicate lower costs on dexmedetomidine. For a conservative approach, the standard sedative acquisition costs were set to zero.