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Table 1 Number of significantly changed metabolites and metabolic super-pathways that they belong to, determined for LPS-challenged subjects and patient groups

From: Human metabolic response to systemic inflammation: assessment of the concordance between experimental endotoxemia and clinical cases of sepsis/SIRS

  

LPS (number = 15)

Sepsis (number = 121)

SIRS (number = 29)

Super pathway

Total

t6

t0

t24

t0

t24

Amino acid

55

28

3

5

3

4

Carbohydrate

16

4

1

2

2

2

Cofactors and vitamins

7

3

2

1

2

1

Lipid

75

36

10

16

12

16

Energy

4

4

0

1

1

1

Nucleotide

8

3

0

0

1

0

Peptide

3

3

0

0

0

0

Xenobiotics

9

2

3

1

0

1

Total

177

83

19

26

21

25

  1. Significance was determined by comparing responses of each group of patients, as well as endotoxemia subjects, to the healthy baseline (t0,LPS) individually. Welch’s t-test was used and with correction for multiple comparisons by the Benjamini and Hochberg procedure. (α = 0.05). Metabolites having a P- and a q-value less than 0.05 are called significant. (The complete list is available in Additional file 3: Table S2). LPS, lipopolysaccharide; SIRS, severe inflammatory response syndrome.
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Critical Care

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