Figure 2From: Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice Increasing the inspiratory time and I:E ratio during MV increased mortality in VILI. Mice were mechanically ventilated for 4 hours with either low tidal volume (LVT 9 ml/kg) or high tidal volume (HVT 34 ml/kg) and an inspiratory/expiratory ratio of 1:2 or 1:1, respectively. If the mean arterial pressure decreased below 40 mm Hg, the experiment was prematurely terminated, as this predicts death with certainty in this model. n = 13-14 each group; ***P < 0.001.Back to article page