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Table 2 Comparison of exposures achieved in this study with other studies (mean (%CV))

From: Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study

  Anidulafungin Caspofungin Fluconazole
Parameter This study (ICU patients) Liu et al. [25] (ICU patients) Liu et al. [25] (healthy volunteers) This study (ICU patients) Wurthwein et al. [26] (general patients) Stone et al. [27]a (healthy volunteers) This studyb (ICU patients) Buijk et al. [23]a (surgical patients) Sobue et al. [24]b (Healthy volunteers, 800 mg)
AUC0–24 55 (28) 93.0 (41) 105.0 (22) 52.0 (53) 170.0 (34) 97.0 (87–109) 359 (259) 409 (336–482) 608 (118)
Cmax 3.9 (29) 7.7 (56) 7.0 (22) 3.9 (55) 13.8 (31) 12.1 (11–13) 20 (14) 25 (22–28) 34 (6)
Cmin 1.8 (30) 3.0 (44) 3.1 (25) 1.5 (57) 4.2 (2.56) 1.4 (1.1–1.8) 14 (11) 15 (10–20) 20 (NR)
  1. aMean (95% CI); bMean (SD). AUC0–24, area under the concentration-time curve from 0 to 24 hours Cmax, observed maximum concentration; Cmin, observed minimum concentration; CV, coefficient of variation; ICU, intensive care unit.