| |
Fluconazole
|
Anidulafungin
|
Caspofungin
|
|---|
|
Number of patients
|
15
|
9
|
6
|
|
Age (years)
|
56 (44–82)
|
51 (41–66)
|
62 (58–72)
|
|
Weight (kg)
|
82 (80–90)
|
81 (76–92)
|
80 (75–85)
|
|
Male sex
|
11 (73)
|
7 (78)
|
5 (71)
|
|
Dose received (mg)
|
400 (200–400)
|
100
|
70 (loading dose)
|
|
Dose (mg/kg)
|
4.9 (2.3–5.0)
|
NA
|
NA
|
|
APACHE II score
|
22 (10–30)
|
18 (15–32)
|
22 (20–26)
|
|
SOFA score
|
7 (5–9)
|
6 (3–7)
|
3 (2–8)
|
|
Serum creatinine concentration (m
Μ
)
|
88 (64–203)
|
119 (47–228)
|
258 (117–286)
|
|
Measured creatinine clearance (ml/min)
|
45 (14–103)
|
62 (15–113)
|
NA
|
- Data are described as median [1st to 3rd quartile] or n (%).
- APACHE, Acute Physiology and Chronic Health Evaluation II score; SOFA, sequential Organ Failure Assessment; NA, insufficient patients with measured creatinine clearance/not applicable.
