| Fluconazole | Anidulafungin | Caspofungin |
---|---|---|---|
Number of patients | 15 | 9 | 6 |
Age (years) | 56 (44–82) | 51 (41–66) | 62 (58–72) |
Weight (kg) | 82 (80–90) | 81 (76–92) | 80 (75–85) |
Male sex | 11 (73) | 7 (78) | 5 (71) |
Dose received (mg) | 400 (200–400) | 100 | 70 (loading dose) |
Dose (mg/kg) | 4.9 (2.3–5.0) | NA | NA |
APACHE II score | 22 (10–30) | 18 (15–32) | 22 (20–26) |
SOFA score | 7 (5–9) | 6 (3–7) | 3 (2–8) |
Serum creatinine concentration (m Μ ) | 88 (64–203) | 119 (47–228) | 258 (117–286) |
Measured creatinine clearance (ml/min) | 45 (14–103) | 62 (15–113) | NA |