CLCR(ml/min)
|
CFR, 50%fT>MIC(%) | CFR, 100% fT>MIC(%)
|
|---|
10 |
87.2
|
81.3
|
30 |
86.0
|
80.6
|
60 |
83.5
| 72.6 |
90 | 78.6 | 57.2 |
120 | 71.7 | 40.4 |
150 | 62.7 | 28.5 |
180 | 55.5 | 20.0 |
210 | 46.3 | 13.3 |
240 | 40.8 | 9.9 |
270 | 31.0 | 6.3 |
300 | 28.3 | 4.9 |
-
a50% fT>MIC, 50% time above the minimum inhibitory concentration; 100% fT>MIC, 100% time above the minimum inhibitory concentration; CFR, Cumulative fraction of response; CLCR, Creatinine clearance. Data represent the CFR when targeting 50% fT>MIC and 100% fT>MIC with a range of CLCR values following a 4.5 g piperacillin-tazobactam dose administered every 6 hours as an intermittent 20 minute infusion. The wild-type MIC distrubiton of Pseudomonas aeruginosa has been employed. Boldface represents those CLCR values where target exposures would be achieved in at least 80% of isolates.
