|
CLCR(ml/min)
|
CFR, 50%fT>MIC(%)
|
CFR, 100% fT>MIC(%)
|
|---|
|
10
|
87.2
|
81.3
|
|
30
|
86.0
|
80.6
|
|
60
|
83.5
|
72.6
|
|
90
|
78.6
|
57.2
|
|
120
|
71.7
|
40.4
|
|
150
|
62.7
|
28.5
|
|
180
|
55.5
|
20.0
|
|
210
|
46.3
|
13.3
|
|
240
|
40.8
|
9.9
|
|
270
|
31.0
|
6.3
|
|
300
|
28.3
|
4.9
|
-
a50% fT>MIC, 50% time above the minimum inhibitory concentration; 100% fT>MIC, 100% time above the minimum inhibitory concentration; CFR, Cumulative fraction of response; CLCR, Creatinine clearance. Data represent the CFR when targeting 50% fT>MIC and 100% fT>MIC with a range of CLCR values following a 4.5 g piperacillin-tazobactam dose administered every 6 hours as an intermittent 20 minute infusion. The wild-type MIC distrubiton of Pseudomonas aeruginosa has been employed. Boldface represents those CLCR values where target exposures would be achieved in at least 80% of isolates.
