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Table 3 Cumulative fraction of response for piperacillin over a range of creatinine clearance valuesa

From: Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?

CLCR(ml/min) CFR, 50%fT>MIC(%) CFR, 100% fT>MIC(%)
10 87.2 81.3
30 86.0 80.6
60 83.5 72.6
90 78.6 57.2
120 71.7 40.4
150 62.7 28.5
180 55.5 20.0
210 46.3 13.3
240 40.8 9.9
270 31.0 6.3
300 28.3 4.9
  1. a50% fT>MIC, 50% time above the minimum inhibitory concentration; 100% fT>MIC, 100% time above the minimum inhibitory concentration; CFR, Cumulative fraction of response; CLCR, Creatinine clearance. Data represent the CFR when targeting 50% fT>MIC and 100% fT>MIC with a range of CLCR values following a 4.5 g piperacillin-tazobactam dose administered every 6 hours as an intermittent 20 minute infusion. The wild-type MIC distrubiton of Pseudomonas aeruginosa has been employed. Boldface represents those CLCR values where target exposures would be achieved in at least 80% of isolates.