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Table 2 Mean parameter estimates and bootstrap mean (95% confidence interval) estimates for the final population pharmacokinetic modela

From: Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?

Parameter Model Bootstrap
  Mean Mean 95% confidence interval
    2.5% 97.5%
Fixed effects
  CL (L/hr) 16.3 16.2 14.0 18.9
  Vc (L) 19.9 15.9 0.7 27.8
  Vp (L) 18.8 21.3 11.1 32.3
  Q (L/h) 37.3 42.9 22.0 73.3
  ALAG (hr) 0.8 0.13 0.01 0.31
Random effects BSV (% CV)
  CL (L/hr) 56.0 55.3 45.2 65.4
  Vc (L) 29.6 23.5 0.2 45.7
  Vp (L) 67.6 69.2 24.6 158.4
  ALAG (hr) 0.3 0.4 0.05 0.8
Random error
  RUV (% CV) 1.0 1.3 0.3 3.1
  RUV (SD, mg/L) 0.3 0.3 0.2 0.4
  1. aALAG, Infusion lag time; BSV, Between-subject variability; CL, Clearance; CV, Coefficient of variation; Q, Intercompartmental clearance; RUV, Residual unexplained variability; SD, Standard deviation; Vc, Volume of the central compartment; Vp, Volume of the peripheral compartment.