|
Parameter
|
Model
|
Bootstrap
|
|---|
| |
Mean
|
Mean
|
95% confidence interval
|
|---|
| | | |
2.5%
|
97.5%
|
|---|
|
Fixed effects
|
| |
CL (L/hr)
|
16.3
|
16.2
|
14.0
|
18.9
|
| |
Vc (L)
|
19.9
|
15.9
|
0.7
|
27.8
|
| |
Vp (L)
|
18.8
|
21.3
|
11.1
|
32.3
|
| |
Q (L/h)
|
37.3
|
42.9
|
22.0
|
73.3
|
| |
ALAG (hr)
|
0.8
|
0.13
|
0.01
|
0.31
|
|
Random effects BSV (% CV)
|
| |
CL (L/hr)
|
56.0
|
55.3
|
45.2
|
65.4
|
| |
Vc (L)
|
29.6
|
23.5
|
0.2
|
45.7
|
| |
Vp (L)
|
67.6
|
69.2
|
24.6
|
158.4
|
| |
ALAG (hr)
|
0.3
|
0.4
|
0.05
|
0.8
|
|
Random error
|
| |
RUV (% CV)
|
1.0
|
1.3
|
0.3
|
3.1
|
| |
RUV (SD, mg/L)
|
0.3
|
0.3
|
0.2
|
0.4
|
-
aALAG, Infusion lag time; BSV, Between-subject variability; CL, Clearance; CV, Coefficient of variation; Q, Intercompartmental clearance; RUV, Residual unexplained variability; SD, Standard deviation; Vc, Volume of the central compartment; Vp, Volume of the peripheral compartment.
