Figure 1

Piperacillin concentrations over time grouped according to creatinine clearance quartile. Mean piperacillin concentration (log10 scale) and time grouped according to creatinine clearance (CLCR) quartile: <68 ml/min (black diamonds), 68 to 114 ml/min (grey diamonds), 115 to 170 ml/min (black squares) and >170 ml/min (grey squares). The dotted line at 16 mg/L represents minimum inhibitory concentration.