Table 1 Demographic and clinical characteristics of 27 burn patients
Corticosteroids (n = 12) | Placebo (n = 15) | Total (n = 27) | P value | |
|---|---|---|---|---|
Demographic characteristics | ||||
Age (years) | 48 [46-50] | 48 [36-58] | 48 [39-54] | 0.90 |
Gender (males) | 10 (83%) | 9 (60%) | 19 (70%) | 0.24 |
Weight (usual), kg | 73 [69-83] | 80 [68-93] | 76 [68-85] | 0.57 |
Weight at inclusion, kg | 92 [80-96] | 100 [81-112] | 94 [80-103] | 0.22 |
Severity | ||||
Total burn surface area (%) | 66 [50-85] | 62 [44-76] | 62 [47-81] | 0.31 |
Baux score | 115 [101-128] | 108 [100-113] | 108 [100-123] | 0.35 |
ABSI score | 12 [11-13] | 11 [10-12] | 11 [10-12] | 0.19 |
Clinical characteristics prior inclusion | ||||
Delay burn - inclusion (h) | 60 [54-65] | 45 [41-58] | 54 [43-62] | 0.03 |
Inhalation injury | 7 (58%) | 3 (20%) | 10 (37%) | 0.06 |
Etomidate administration | 3 (27%) | 12 (80%) | 15 (58%) | 0.02 |
Norepinephrine (μg/kg/min) | 0.57 [0.51-0.62] | 0.60 [0.51-0.92] | 0.60 [0.50-0.70] | 0.45 |
Blood transfusions | 1 (8%) | 2 (13%) | 3 (11%) | 1.00 |
FiO2 (%) | 40 [30-45] | 40 [40-50] | 40 [35-50] | 0.13 |
PEEP (cmH2O) | 4 [4,5] | 6 [5-7] | 5 [4-6] | 0.17 |
Diuresis (mL/24 h) | 3,925 [3,175-4,400] | 3,500 [3,050-4,250] | 3,600 [3,150-4,400] | 0.59 |
Biology | ||||
Relative adrenal insufficiency | 9 (75%) | 12 (80%) | 21 (78%) | 1.00 |
Basal cortisol (μg/dL) | 15 [9-18] | 11 [8-16] | 14 [8-17] | 0.39 |
Delta cortisol after-before corticotropin test (μg/dL) | 12 [7-17] | 9 [5-13] | 10 [6-14] | 0.32 |
Plasma creatinine (μmol/L) | 78 [75-91] | 92 [72-103] | 80 [73-103] | 0.68 |
Plasma protein (g/L) | 43 [38-46] | 41 [38-45] | 42 [38-45] | 0.71 |
Plasma albumin (g/L) | 29 [27-31] | 29 [28-31] | 29 [27-31] | 0.86 |
Hemoglobin (g/L) | 111 [104-120] | 113 [90-132] | 113 [100-125] | 0.98 |
WBCC (109/L) | 4 [3-7] | 7 [4-11] | 6 [3-10] | 0.13 |
Lymphocyte count (109/L) | 0.85 [0.61-1.25] | 1.15 [0.92-1.43] | 1 [0.72-1.37] | 0.15 |
RCT end points | ||||
Norepinephrine duration (h) | 57 [38-113] | 120 [84-141] | 96 [57-129] | 0.03 |
Norepinephrine quantity (μg/kg) | 1,205 [1,079-2,167] | 1,971 [1,535-3,893] | 1,755 [1,174-3,188] | 0.07 |
Septic shock | 4 (33%) | 7 (47%) | 11 (41%) | 0.70 |
Infections per patient | 2 [1-3] | 2 [2,3] | 2 [2-3] | 0.43 |
Skin grafting per patient | 6 [4-7] | 5 [4-10] | 6 [4-9] | 0.45 |
Stay in ICU (days) | 63 [27-77] | 62 [41-81] | 62 [39-78] | 0.69 |
Stay in hospital (days) | 73 [54-85] | 84 [58-104] | 75 [58-97] | 0.45 |
Death before D28 | 6 (38%) | 2 (13%) | 8 (25%) | 0.57 |