Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial

Table 3 Fluid administration and fluid balance

	Control	Preload dependence	P
	(n = 30)	(n = 30)	P
Intravascular volume expansion ITT (mL.day^-1)	986 [654-1,624]	446 [295-1,105]	0.04
Intravascular volume expansion PP (mL.day^-1)	917 [639-1,511]	383 [211-604]	0.01
RBC transfusion (mL.day^-1)	178 [82-304]	103 (0-183]	0.04
Other blood products (mL.day^-1)	0 [0-122]	0 [0-125]	0.76
Other fluids (mL.day^-1)	3151 [2,791-3,456]	2919 [2,533-3,368]	0.70
Fluid intake^* (mL.day^-1)	4096 [3,770-4,677]	3610 [2,982-4,560]	0.16
Diuresis (mL.day^-1)	2116 [368-3,212]	1854 [513-3,332]	0.95
Fluid output (mL.day^-1)	2550 [1,914-3,331]	2609 [2,079-3,202]	0.95
Fluid balance (mL.day^-1)	1749 [146-2,788]	888 [153-2,816]	0.68
Intravascular volume expansion/fluid intake (%)	23%	15%	0.04

Data are median [interquartile range] or number of patients (%). ^*total volume of fluids administered (intravascular volume expansion + blood products + other fluids). ITT, intention to treat; PP, per protocol; RBC, red blood cells.

ISSN: 1364-8535