Table 1 General characteristics at admission and inclusion
Control | Preload dependence | P | |
|---|---|---|---|
(n = 30) | (n = 30) | ||
Age (years) | 64 [54-76] | 65 [58-80] | 0.38 |
Male gender | 22 (73%) | 21 (70%) | 1 |
Admission category | |||
Medical | 27 (90%) | 30 (100%) | 0.24 |
Unscheduled surgery | 3 (10%) | 0 (0%) | |
Charlson score | 3 [2-5] | 3 [1-5] | 0.74 |
Immunodeficiency* | 9 (30%) | 9 (30%) | 1 |
SAPS II | 56 [50-60] | 57 [47-69] | 0.55 |
SOFA score at inclusion | 10 [9-12] | 11 [9-13] | 0.52 |
Time between hypotension and inclusion (H) | 9 [5-11] | 10 [6-11] | 0.64 |
Time between ICU admission and inclusion (H) | 8 [4-15] | 6 [3-12] | 0.55 |
Renal replacement therapy | 6 (20%) | 8 (27%) | 0.76 |
Mechanical ventilation | 26 (87%) | 20 (67%) | 0.13 |
Volume of IV fluids administered between hypotension and inclusion (L) | 3.0 [2.5-4.0] | 3.5 [2.5-4.4] | 0.26 |
Type of infection | |||
Community-acquired infection | 23 (77%) | 21 (70%) | 0.77 |
Hospital-acquired infection | 7 (23%) | 9 (30%) | |
Infection site | |||
Pulmonary | 16 (53%) | 18 (60%) | 0.80 |
Intra-abdominal | 5 (17%) | 7 (23%) | 0.75 |
Urinary tract | 3 (10%) | 6 (20%) | 0.47 |
Catheter-related infection | 1 (3%) | 3 (10%) | 0.61 |
Other | 3 (10%) | 4 (13%) | 1 |
Positive blood cultures | 15 (50%) | 15 (50%) | 1 |
Identification of causative pathogen | 25 (83%) | 27 (90%) | 0.71 |
Causative pathogens | |||
Enterobacteriaceae | 13 (43%) | 16 (53%) | 0.61 |
Non-fermenting gram-negative bacilli | 5 (17%) | 3 (10%) | 0.71 |
Other gram-negative bacilli | 2 (7%) | 4 (13%) | 0.67 |
Staphylococci | 6 (20%) | 7 (23%) | 1 |
Streptococci | 2 (7%) | 6 (20%) | 0.25 |
Gram-positive bacilli | 0 (0%) | 1 (3%) | 1 |
Enterococci | 0 (0%) | 1 (3%) | 1 |
Gram-negative cocci | 0 (0%) | 1 (3%) | 1 |
Fungi | 0 (0%) | 1 (3%) | 1 |
Empirical antibiotic therapy | |||
Adequate | 24 (80%) | 23 (77%) | 0.42 |
Inadequate | 1 (3%) | 4 (13%) | |
Not applicable | 5 (17%) | 3 (10%) |