Rs1800625 in the receptor for advanced glycation end products gene predisposes to sepsis and multiple organ dysfunction syndrome in patients with major trauma

Table 4 Clinical relevance of rs1800625 among trauma patients in the three cohorts

	Genotypes	N	Age (yr)	Sex (M/F)	ISS	Sepsis, n/%	MODS score
Chongqing	TT	620	40.8 ± 13.1	494/126	22.6 ± 9.3	275 (46.8%)	6.9 ± 2.2
	TC	195	41.9 ± 14.5	157/38	21.5 ± 9.7	65 (33.3%)	6.0 ± 2.0
	CC	22	41.0 ± 11.4	21/1	20.0 ± 9.4	6 (27.3%)	5.2 ± 1.7
						a1	a2, b1
Zhejiang	TT	271	42.3 ± 12.7	212/59	21.7 ± 7.7	113 (41.7%)	7.5 ± 2.5
	TC	65	42.8 ± 16.2	50/15	21.9 ± 7.6	15 (23.1%)	6.8 ± 2.6
	CC	4	45.8 ± 19.8	4/0	18.8 ± 6.5	1 (25.0%)	5.9 ± 3.1
						a3	a4
Yunnan	TT	269	37.4 ± 12.5	208/61	21.3 ± 9.0	103 (38.3%)	7.2 ± 2.0
	TC	86	38.7 ± 12.0	64/22	20.8 ± 9.8	24 (27.9%)	6.3 ± 2.1
	CC	12	33.8 ± 14.4	10/2	24.8 ± 8.7	3 (25.0%)	5.8 ± 2.6
						a5	a6

a: dominant effect (variant homozygotes + heterozygotes vs. wild homozygotes) as analyzed by ANCOVA, ^a1 P = 0.002, ^a2 P = 0.001, ^a3 P = 0.003, ^a4 P = 0.032, ^a5 P = 0.047, ^a3 P = 0.016, ^a4 P = 0.042, ^a5 P = 0.012, ^a6 P = 0.026; b: recessive effect (variant homozygotes vs. heterozygotes + wild homozygotes) as analyzed by ANCOVA, ^b1 P = 0.032. ISS. Injury Severity Score; MODS, multiple organ dysfunction syndrome.

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